Anti-nephrin autoantibodies: a paradigm shift in podocytopathies

IF 28.6 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Nephrology Pub Date : 2024-07-30 DOI:10.1038/s41581-024-00873-7

Zhao Cui, Ming-hui Zhao

引用次数: 0

Abstract

A new study demonstrates that anti-nephrin autoantibodies are not merely markers but also actively contribute to the pathogenesis of minimal change disease and primary focal segmental glomerulosclerosis. This insight not only provides a non-invasive diagnostic alternative to kidney biopsies, but also suggests potential for novel targeted therapies.

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抗胰岛素自身抗体：荚膜细胞病的范式转变。

一项新的研究表明，抗肾上腺素自身抗体不仅仅是一种标记物，它还能积极促进微小病变和原发性局灶节段性肾小球硬化症的发病机制。这一见解不仅为肾活检提供了一种非侵入性诊断替代方法，而且还为新型靶向疗法提供了潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Nephrology 医学-泌尿学与肾脏学

CiteScore

39.00

自引率

1.20%

发文量

127

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.