Rachel C Hill, Willian De Faria, Jeremy A W Gold, Shari R Lipner
{"title":"Factors associated with pityriasis versicolor in a large national database.","authors":"Rachel C Hill, Willian De Faria, Jeremy A W Gold, Shari R Lipner","doi":"10.1111/myc.13775","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pityriasis versicolor (PV), a cutaneous fungal infection, most commonly affects adolescents and young adults and is associated with hyperhidrosis and humid weather. Understanding other factors associated with PV might help improve diagnostic and treatment practices.</p><p><strong>Objectives: </strong>PV's associations with patient demographics, comorbidities and medication exposures were assessed using the All of Us Database, a large, diverse, national database from the United States.</p><p><strong>Methods: </strong>A case-control study with multivariable analysis was performed.</p><p><strong>Results: </strong>We identified 456 PV case-patients and 1368 control-patients. PV case-patients (vs. control-patients) were younger (median age [years] (standard deviation): 48.7 (15.4) vs. 61.9 (15.5); OR: 0.95, CI: 0.94-0.96) and more likely to be men versus women (42.8% vs. 33.9%, OR: 1.45, CI: 1.16-1.79) and Black (19.5% vs. 15.8%, OR: 1.35, 95% CI: 1.02-1.80) or Asian (4.6% vs. 2.7%, OR: 1.86, CI: 1.07-3.24) versus White. PV case-patients more frequently had acne (5.3% vs. ≤1.5%, OR: 5.37, CI: 2.76-10.48) and less frequently had type 2 diabetes mellitus (T2DM) (14.7% vs. 24.7%, OR: 0.52, CI: 0.39-0.70) and hypothyroidism (OR: 10.3% vs. 16.4%, OR: 0.59, CI: 0.42-0.82). In multivariable analysis, PV odds were significantly higher in those with acne and lower in those with T2DM, older age and female sex.</p><p><strong>Conclusions: </strong>Our results may be used as a basis for future studies evaluating whether acne treatment may decrease PV risk. Physicians could educate patients with acne about PV, including strategies to control modifiable PV risk factors, such as avoidance of hot and humid environments and avoidance of use of topical skin oils.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 8","pages":"e13775"},"PeriodicalIF":4.1000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409176/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mycoses","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/myc.13775","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Pityriasis versicolor (PV), a cutaneous fungal infection, most commonly affects adolescents and young adults and is associated with hyperhidrosis and humid weather. Understanding other factors associated with PV might help improve diagnostic and treatment practices.
Objectives: PV's associations with patient demographics, comorbidities and medication exposures were assessed using the All of Us Database, a large, diverse, national database from the United States.
Methods: A case-control study with multivariable analysis was performed.
Results: We identified 456 PV case-patients and 1368 control-patients. PV case-patients (vs. control-patients) were younger (median age [years] (standard deviation): 48.7 (15.4) vs. 61.9 (15.5); OR: 0.95, CI: 0.94-0.96) and more likely to be men versus women (42.8% vs. 33.9%, OR: 1.45, CI: 1.16-1.79) and Black (19.5% vs. 15.8%, OR: 1.35, 95% CI: 1.02-1.80) or Asian (4.6% vs. 2.7%, OR: 1.86, CI: 1.07-3.24) versus White. PV case-patients more frequently had acne (5.3% vs. ≤1.5%, OR: 5.37, CI: 2.76-10.48) and less frequently had type 2 diabetes mellitus (T2DM) (14.7% vs. 24.7%, OR: 0.52, CI: 0.39-0.70) and hypothyroidism (OR: 10.3% vs. 16.4%, OR: 0.59, CI: 0.42-0.82). In multivariable analysis, PV odds were significantly higher in those with acne and lower in those with T2DM, older age and female sex.
Conclusions: Our results may be used as a basis for future studies evaluating whether acne treatment may decrease PV risk. Physicians could educate patients with acne about PV, including strategies to control modifiable PV risk factors, such as avoidance of hot and humid environments and avoidance of use of topical skin oils.
背景：多汗症（PV）是一种皮肤真菌感染，最常见于青少年和年轻人，与多汗症和潮湿天气有关。了解与真菌性皮肤病相关的其他因素可能有助于改进诊断和治疗方法：方法：使用美国大型、多样化的全国性数据库 "All of Us Database "评估了真皮病变与患者人口统计学特征、合并症和药物接触的关系：方法：进行病例对照研究和多变量分析：结果：我们发现了 456 例肺结核病例患者和 1368 例对照组患者。中位年龄[岁]（标准偏差）：48.7（15.4）：48.7 (15.4) vs. 61.9 (15.5)；OR：0.95，CI：0.94-0.96），男性多于女性（42.8% vs. 33.9%，OR：1.45，CI：1.16-1.79），黑人（19.5% vs. 15.8%，OR：1.35，95% CI：1.02-1.80）或亚裔（4.6% vs. 2.7%，OR：1.86，CI：1.07-3.24）多于白人。PV病例患者更常见的是痤疮（5.3% vs. ≤1.5%，OR：5.37，CI：2.76-10.48），较少见的是2型糖尿病（T2DM）（14.7% vs. 24.7%，OR：0.52，CI：0.39-0.70）和甲状腺功能减退症（OR：10.3% vs. 16.4%，OR：0.59，CI：0.42-0.82）。在多变量分析中，痤疮患者的PV几率明显较高，而T2DM、年龄较大和女性患者的PV几率较低：我们的研究结果可作为今后评估痤疮治疗是否可降低PV风险研究的基础。医生可以对痤疮患者进行有关真性红斑狼疮的教育，包括控制可改变的真性红斑狼疮风险因素的策略，如避免湿热环境和避免使用外用皮肤油。
期刊介绍：
The journal Mycoses provides an international forum for original papers in English on the pathogenesis, diagnosis, therapy, prophylaxis, and epidemiology of fungal infectious diseases in humans as well as on the biology of pathogenic fungi.
Medical mycology as part of medical microbiology is advancing rapidly. Effective therapeutic strategies are already available in chemotherapy and are being further developed. Their application requires reliable laboratory diagnostic techniques, which, in turn, result from mycological basic research. Opportunistic mycoses vary greatly in their clinical and pathological symptoms, because the underlying disease of a patient at risk decisively determines their symptomatology and progress. The journal Mycoses is therefore of interest to scientists in fundamental mycological research, mycological laboratory diagnosticians and clinicians interested in fungal infections.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
