The therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.

IF 1.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of International Medical Research Pub Date : 2024-07-01 DOI:10.1177/03000605241263166

Fang Xiong, Zongjun Hu, Chao Liu, Kexiang Zhang, Qilong Zhou, Jianguo Chen, Hua Lu, Xi Yue, Jianxin Zhao, Pengfei Pan

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引用次数: 0

Abstract

Objective: To explore the therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.

Method: Patients with prolonged ventilator weaning and cardiac dysfunction were randomly allocated to receive conventional treatment (control group) or intravenous infusion of levosimendan for 24 h based on conventional treatment (levosimendan group). Weaning success rates were then compared between the two groups. The study was retrospectively registered with Research Registry (ID No. researchregistry10304).

Results: A total of 40 patients were included (20 per group). Within 3 days after initiation of treatment, significantly more cases were successfully weaned in the levosimendan group versus control group (eight versus four cases, respectively). Among the eight patients who underwent pulse indicator continuous cardiac output monitoring in the levosimendan group, the global ejection fraction increased 24 h after treatment, and the cardiac function index and cardiac index increased 72 h after treatment.

Conclusion: For patients requiring prolonged mechanical ventilation who have concomitant cardiac dysfunction, levosimendan may be considered to increase the probability of weaning success.

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左西孟旦对长期呼吸机断流和心功能不全患者的治疗效果。

目的：探讨左西孟旦对长期呼吸机断流和心功能不全患者的治疗效果：探讨左西孟旦对呼吸机断流时间长且心功能不全患者的治疗效果：方法：将呼吸机断流时间过长并伴有心功能不全的患者随机分配到常规治疗组（对照组）或在常规治疗基础上静脉输注左西孟旦24小时的治疗组（左西孟旦组）。然后比较两组的断奶成功率。该研究已在研究登记处进行了回顾性登记（编号：researchregistry10304）：共纳入 40 例患者（每组 20 例）。开始治疗后 3 天内，左西孟旦组成功断奶的病例明显多于对照组（分别为 8 例和 4 例）。在左西孟旦组接受脉冲指示器连续心输出量监测的 8 名患者中，治疗 24 小时后总射血分数增加，治疗 72 小时后心功能指数和心脏指数增加：结论：对于需要长期机械通气且伴有心功能不全的患者，可考虑使用左西孟旦以提高断流成功的概率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Medical Research 医学-药学

CiteScore

3.20

自引率

0.00%

发文量

555

审稿时长

1 months

期刊介绍： _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605