Clinical Management of Familial Hypercholesterolemia in Children.

IF 1.3 Q3 PEDIATRICS
Kurt Widhalm, Karin Fallmann
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引用次数: 0

Abstract

Familial Hypercholesterolemia (FH) is one of the best-characterized inborn errors of metabolism, with an estimated prevalence of 1:250 in the general population. Only approximately 10% of the affected subjects are diagnosed and, therefore, under medical care, including drug therapy or, in severe cases, apheresis. Screening at the age of 6-10 years would be useful and cost-effective. There is enough evidence that children and adolescents with FH should be treated in order to reduce elevated Total cholesterol and LDL-c levels and, therefore, avoid the risk of early cardiovascular diseases. As FH was described more than 130 years ago, it is surprising that the knowledge of that very important metabolic disorder is insufficient. The present report describes clinical and pathophysiological characteristics and nutritional and medical therapies in children with familial hypercholesterolemia.

儿童家族性高胆固醇血症的临床治疗。
家族性高胆固醇血症(FH)是特征最明显的先天性代谢异常之一,在普通人群中的发病率估计为 1:250。只有约 10%的患者被确诊,并因此接受药物治疗等医疗护理,严重者还需接受血液透析治疗。在 6-10 岁时进行筛查既有用又经济。有足够的证据表明,患有 FH 的儿童和青少年应接受治疗,以降低升高的总胆固醇和低密度脂蛋白胆固醇水平,从而避免早期心血管疾病的风险。由于 FH 早在 130 多年前就已被描述,因此人们对这种非常重要的代谢性疾病的认识不足令人惊讶。本报告介绍了家族性高胆固醇血症儿童的临床和病理生理学特征以及营养和药物疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
66
期刊介绍: Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
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