Beyond the appearances: exploring complexities in anaphylaxis differential diagnosis.

IF 3 4区医学 Q2 ALLERGY

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI:10.1097/ACI.0000000000001016

Stefania Nicola, Luca Lo Sardo, Richard Borrelli, Anna Quinternetto, Nicolò Rashidy, Luisa Brussino

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Abstract

Purpose of review: Anaphylaxis is a severe, and potentially life-threatening hypersensitivity reaction whose diagnosis is based on clinical signs and symptoms and their prompt recognition. The presence of mimics and unusual presentations necessitate a careful evaluation and expertise in the field, due to potential diagnostic errors and hence a delay in the treatment.The aim of this review is to analyze and make an overview of the potential differential diagnosis of anaphylaxis, focusing on the clinical challenges of recognizing these conditions effectively among similar others.

Recent findings: The presence of mimics and unusual presentations of anaphylaxis necessitate a careful evaluation, emphasizing the importance of a comprehensive diagnostic approach.Tryptase is well known marker of mast cells activation, and a useful tool assisting the diagnosis of anaphylaxis, helping to differentiate it from atypical mimickers.

Summary: The differential diagnosis of anaphylaxis comprises a very wide setting, and a systematic approach assessing different categories of cardiovascular, skin, respiratory airway, neuropsychiatric, and hematologic systems, can facilitate recognition of the correct diagnosis of this complex and life-threatening condition.

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超越表象：探索过敏性休克鉴别诊断的复杂性。

审查目的：过敏性休克是一种严重的、可能危及生命的超敏反应，其诊断依据是临床症状和体征以及对其的及时识别。本综述旨在分析和概述过敏性休克的潜在鉴别诊断，重点关注在类似情况中有效识别这些病症所面临的临床挑战：胰蛋白酶是众所周知的肥大细胞活化标志物，也是辅助诊断过敏性休克的有用工具，有助于将过敏性休克与非典型拟态休克区分开来。摘要：过敏性休克的鉴别诊断范围很广，采用系统的方法评估心血管、皮肤、呼吸气道、神经精神和血液系统的不同类别，有助于识别这一复杂且危及生命的疾病的正确诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Allergy and Clinical Immunology 医学-过敏

CiteScore

5.90

自引率

3.60%

发文量

109

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.