Efficacy of antimicrobial peptide P113 oral health care products on the reduction of oral bacteria number and dental plaque formation in a randomized clinical assessment

IF 3.4 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
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Abstract

Background/purpose

Dental plaque is the main cause leading to the dental caries and periodontal diseases. The main purpose of this study was to test the efficacy of oral spray containing the antimicrobial peptide P-113 on the reduction of oral bacteria number and dental plaque formation in a randomized clinical assessment.

Materials and methods

This study was divided into two parts. In Part A, we investigated the user experiences with the P-113 containing oral spray. In part B, 14 subjects in the experimental group used the P-113-containing oral spray, while 14 subjects in the control group used a placebo without the P-113 in a 4-week clinical trial. Participants were asked to use the P-113-containing oral spray or placebo 3 times per day and 5 times per use. Moreover, 3 check-ups and 2 washouts were carried out to evaluate the DMFT score, dental plaque weight, dental plaque index, and gingival index.

Results

In part A, up to 91.8% of the subjects in the experimental group were satisfied with the use of the P-113-containing oral spray. In part B, based on our PacBio SMRT sequencing platform and DADA2 analysis, the numbers of Streptococcus and Porphyromonas in the experimental group were lower than those in the control group. In addition, decreased dental plaque weight, dental plaque index, and gingival index were all observed in the experimental group.

Conclusion

The P-113-containing oral spray has the potential to reduce the dental caries and periodontal disease-related bacteria and to control the dental plaque formation.

在一项随机临床评估中,抗菌肽 P113 口腔保健产品对减少口腔细菌数量和牙菌斑形成的功效
背景/目的牙菌斑是导致龋齿和牙周疾病的主要原因。本研究的主要目的是通过随机临床评估,测试含有抗菌肽 P-113 的口腔喷雾剂对减少口腔细菌数量和牙菌斑形成的功效。在 A 部分,我们调查了用户使用含有 P-113 的口腔喷雾剂的体验。在 B 部分中,14 名实验组受试者使用了含 P-113 的口腔喷雾剂,14 名对照组受试者使用了不含 P-113 的安慰剂,进行了为期 4 周的临床试验。要求受试者每天使用含 P-113 的口服喷雾剂或安慰剂 3 次,每次使用 5 次。结果在 A 部分中,高达 91.8%的实验组受试者对使用含 P-113 的口腔喷雾剂感到满意。在 B 部分,根据我们的 PacBio SMRT 测序平台和 DADA2 分析,实验组的链球菌和卟啉单胞菌数量低于对照组。结论 含 P-113 的口腔喷雾剂具有减少龋齿和牙周病相关细菌以及控制牙菌斑形成的潜力。
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来源期刊
Journal of Dental Sciences
Journal of Dental Sciences 医学-牙科与口腔外科
CiteScore
5.10
自引率
14.30%
发文量
348
审稿时长
6 days
期刊介绍: he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.
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