Association between dietary protein intake and mortality among patients with diabetic kidney disease

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM
Yichuan Wu , Jiaqi Chen , Yuan Tao , Manlu Xiao , Jingrong Xiong , Aomiao Chen , Xiaoqin Ma , Linna Li , Hongxia Jia , Qian Zhang , Yaoming Xue , Yijie Jia , Zongji Zheng
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引用次数: 0

Abstract

Aims

This study aimed to investigate the association between dietary protein intake and mortality among patients with diabetic kidney disease.

Methods

The research encompassed a total of 2901 participants diagnosed with diabetic kidney disease, drawn from the National Health and Nutrition Examination Survey (NHANES). To determine outcomes related to all-cause and cardiovascular mortality, connections were established with the National Death Index up until December 31, 2019. Estimations of hazard ratios (HRs) and their corresponding 95 % confidence intervals (CIs) were conducted using Cox proportional hazard ratio models.

Results

During the 261,239 person-years of follow-up, 1236 deaths were recorded. After multivariate adjustment, the weighted hazard ratio (HR) and 95 % CIs for participants with 1.0–1.2 g/kg of protein intake was 0.65 (0.44, 0.96) for all-cause mortality. A higher proportion of animal protein intake was found to be associated with an increased mortality risk. Stratified analyses showed that higher protein intake benefited older participants.

Conclusions

In diabetic kidney disease patients, 1.0–1.2 g/kg of protein was associated with lower mortality and 0.6–1.2 g/kg of protein especially benefitted patients ≥60 years.

膳食蛋白质摄入量与糖尿病肾病患者死亡率之间的关系
目的本研究旨在调查糖尿病肾病患者膳食蛋白质摄入量与死亡率之间的关系。方法本研究从美国国家健康与营养调查(NHANES)中抽取了2901名确诊为糖尿病肾病的参与者。为了确定与全因死亡率和心血管死亡率相关的结果,研究人员与截至 2019 年 12 月 31 日的国家死亡指数建立了联系。结果在 261239 人年的随访期间,共记录了 1236 例死亡。经过多变量调整后,蛋白质摄入量为 1.0-1.2 克/千克的参与者全因死亡率的加权危险比 (HR) 和 95 % CI 为 0.65 (0.44, 0.96)。研究发现,动物蛋白摄入比例越高,死亡风险越高。结论在糖尿病肾病患者中,每公斤 1.0-1.2 克蛋白质与降低死亡率有关,每公斤 0.6-1.2 克蛋白质尤其有益于年龄≥60 岁的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
22.90
自引率
2.00%
发文量
248
审稿时长
51 days
期刊介绍: Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.
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