Immune-regulating effect of oxytocin and its association with the hypothalamic-pituitary axes

IF 2.9 4区 医学 Q3 IMMUNOLOGY
Tong Li , Yun-Hao Jiang , Xiaoran Wang , Dan Hou , Shu-Wei Jia , Yu-Feng Wang
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引用次数: 0

Abstract

Oxytocin can regulate immunological activity directly or indirectly; however, immunological functions and mechanisms of oxytocin actions under chronic stress like cesarean delivery (CD) are poorly understood. Our study found that abnormal oxytocin production and secretion in CD rats caused atrophy of thymic tissues. Neurotoxin kainic acid microinjected into the dorsolateral supraoptic nucleus in male rats selectively reduced hypothalamic oxytocin levels, increased corticotrophin-releasing hormone and plasma interleukin-1β while reducing plasma oxytocin, thyroxine and testosterone levels and causing atrophy of immune tissues. Thus, plasma oxytocin is essential for immunological homeostasis, which involves oxytocin facilitation of thyroid hormone and sex steroid secretion.

催产素的免疫调节作用及其与下丘脑-垂体轴的联系
催产素可直接或间接调节免疫活动;然而,人们对催产素在剖宫产(CD)等慢性应激状态下的免疫功能和作用机制知之甚少。我们的研究发现,CD 大鼠催产素的产生和分泌异常会导致胸腺组织萎缩。向雄性大鼠背外侧视上核微量注射神经毒素凯尼酸可选择性地降低下丘脑催产素水平,增加促肾上腺皮质激素释放激素和血浆白细胞介素-1β,同时降低血浆催产素、甲状腺素和睾酮水平,导致免疫组织萎缩。因此,血浆催产素对免疫平衡至关重要,这涉及催产素对甲状腺激素和性类固醇分泌的促进作用。
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来源期刊
Journal of neuroimmunology
Journal of neuroimmunology 医学-免疫学
CiteScore
6.10
自引率
3.00%
发文量
154
审稿时长
37 days
期刊介绍: The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.
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