Exploring the Potential of Pectin for Gastro Retentive Drug Delivery Systems: From Orchard to Drug Delivery

IF 0.3 Q4 PHARMACOLOGY & PHARMACY

Current Drug Therapy Pub Date : 2024-07-19 DOI:10.2174/0115748855310489240710114905

R. Pahwa, Neha Rao, R. Awasthi, Jasmine Sagwal, H. Dureja

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Abstract

Significant progress has been made in the field of gastroretentive drug delivery systems using natural polysaccharides. These improvements aim to improve the effectiveness and absorption of different medicinal agents. Pectin has received substantial attention in recent years due to its distinctive structural characteristics, abundant availability, biocompatibility, lack of toxicity, and wide range of applications. The global utilization of pectin in drug delivery systems has expanded significantly. Pectin is used to achieve flotation and mucoadhesive properties, which enhance gastric residence length and improve therapeutic effectiveness. The article aims to comprehensively examine the information on several pectin-based formulations for medication delivery that are designed to remain in the stomach for an extended period of time. Furthermore, this article emphasizes the diverse physicochemical and biological properties of pectin and modified pectin, as well as their prospective uses in numerous fields. This publication also presents the significant advantages, challenges, potential future developments, and patents on pectin-based gastroretentive drug delivery systems.

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探索果胶用于胃保留药物输送系统的潜力：从果园到药物输送

利用天然多糖开发的胃肠道给药系统取得了重大进展。这些改进旨在提高不同药物的有效性和吸收率。近年来，果胶因其独特的结构特征、丰富的可获得性、生物相容性、无毒性和广泛的应用范围而受到广泛关注。果胶在全球给药系统中的应用已显著扩大。果胶具有浮游性和粘附性，能延长药物在胃中的停留时间，提高疗效。本文旨在全面研究几种基于果胶的给药配方的相关信息，这些配方旨在延长在胃中的停留时间。此外，本文还强调了果胶和改性果胶的各种物理化学和生物学特性，以及它们在众多领域的应用前景。本文还介绍了基于果胶的胃黏膜给药系统的显著优势、挑战、未来潜在发展和专利。

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来源期刊

Current Drug Therapy PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.