Biodistribution and Absorption of Radiopharmaceutical 99mTc MDP in Various Bones of Lung Cancer Patients Using SPECT/CT Modalities

Salman Alfarizi, Wahyu Setia Budi, Zaenal Arifin, M. Roeslan Abdul Gani, Junan Imaniar Pribadi
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Abstract

Lung-to-bone cancer metastasis frequently involves bone lesions, particularly in the vertebrae. A bone scan using the radiopharmaceutical 99mTc MDP is a common diagnostic tool for detecting advanced metastases. This research aimed to determine the conversion factor of count rate to unit activity, assess the range of source activity in bones with and without lesions, and analyze the relationship between lung cancer metastasis and radiopharmaceutical activity in various bones. The study involved 28 patients. Procedures included phantom manufacturing, determining the depth of Antero Posterior (AP) and Postero Anterior (PA) position bones, converting count rates to activity units, and assessing 99mTc MDP biodistribution in bones. Results indicated that the conversion factor of count rate to activity units in AP and PA positions for lumbar vertebrae, costa vera, ilium, and sacrum were (〖13.2×10〗^(-4); 4.9〖×10〗^(-4)) mCi/cps; (4.0〖×10〗^(-4); 4.4〖×10〗^(-4)) mCi/cps; (4.0〖×10〗^(-4); 4.9〖×10〗^(-4)) mCi/cps; and (〖12.2×10〗^(-4); 〖4.5×10〗^(-4)) mCi/cps. In addition, there is a range of source activity values and percentage of activity in the bones (lumbar vertebrae; costa vera; ilium; and sacrum), namely (0.019-0.053) mCi and (0.107-0.498)%; (0.020-0.045) mCi and (0.139-0.338)%; (0.024-0.066) mCi and (0.128-0.551)%; and (0.012-0.028) mCi and (0.078-0.264)%. Furthermore, there is a range of source activity values in the lesion-indicated bone (lumbar vertebrae; costa vera; ilium; and sacrum), namely (0.038-0.053) mCi; (0.024-0.045) mCi; (0.033-0.066) mCi; and (0.017-0.028) mCi. The relationship between lung cancer metastasis to various bones studied and the range of radiopharmaceutical activity values obtained is moderately positive.
利用 SPECT/CT 模式研究放射性药物 99mTc MDP 在肺癌患者不同骨骼中的生物分布和吸收情况
肺癌骨转移经常涉及骨病变,尤其是脊椎骨。使用放射性药物 99mTc MDP 进行骨扫描是检测晚期转移灶的常用诊断工具。这项研究旨在确定计数率与单位放射性活度的换算系数,评估有病变和无病变骨骼中放射源放射性活度的范围,并分析肺癌转移与不同骨骼中放射性活度之间的关系。这项研究涉及 28 名患者。程序包括制作模型、确定前方(AP)和后方(PA)位置骨骼的深度、将计数率转换为放射性活度单位,以及评估骨骼中 99mTc MDP 的生物分布。结果表明,腰椎、脊柱、髂骨和骶骨在 AP 和 PA 位置的计数率与活性单位的转换系数分别为〖13.2×10〗^(-4);4.9〖×10〗^(-4))mCi/cps;(4.0〖×10〗^(-4);4.4〖×10〗^(-4))mCi/cps;(4.0〖×10〗^(-4);4.9〖×10〗^(-4))mCi/cps;以及(〖12.2×10〗^(-4);〖4.5×10〗^(-4))mCi/cps。此外,骨骼(腰椎、脊柱、髂骨和骶骨)中的源活度值和活度百分比也有一定范围,即(0.此外,放射性活度源值的范围还包括:(0.024-0.066) mCi 和 (0.128-0.551) %;以及 (0.012-0.028) mCi 和 (0.078-0.264) %。此外,病变指示骨(腰椎、脊柱、髂骨和骶骨)中的放射源活性值也有不同,分别为(0.038-0.053)毫西里、(0.024-0.045)毫西里、(0.033-0.066)毫西里和(0.017-0.028)毫西里。肺癌转移到所研究的各种骨骼与所获得的放射性药物活性值范围之间的关系呈中度正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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