Tina Kianfar, Raquibul Hasan, Yaser Azizi, Fatemeh Ramezani
{"title":"The Effect of Dapagliflozin on Heart Function in Animal Models of\nCardiac Ischemia, A Systematic Review and Meta-analysis","authors":"Tina Kianfar, Raquibul Hasan, Yaser Azizi, Fatemeh Ramezani","doi":"10.2174/0127724328313815240723044625","DOIUrl":null,"url":null,"abstract":"\n\nIn this study, a meta-analysis was conducted to investigate the therapeutic\neffect of Dapagliflozin (DAPA) on animals suffering from myocardial ischemia reperfusion compared to the group that did not receive treatment.\n\n\n\nAccording to the inclusion and exclusion criteria two researchers performed the primary\nand secondary screening based on the title abstract and full text. After data extraction, meta-analysis\nwas performed using STATA software. Standardized mean differences were used to analyze the results of the reported studies. Subgroup analysis and quality control of articles were also conducted\n\n\n\nA total of 21 separate experiments showed that DAPA increased mean fractional shortening (%FS) and ejection fraction (%EF) compared to the untreated animals. A significant reduction\nin the weight and size of the infarcted area and significant increases in dp/dt+\n, dp/dt-\n, left ventricular\nend-systolic internal dimensions (LVIDs), left ventricular end-diastolic internal dimensions\n(LVIDd), Volume systole and Volume diastole were observed in treated animals.\n\n\n\nDAPA has the potential to become a candidate for the treatment of post-ischemic heart\ndamage, pending animal and human studies to validate this.\n","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Reviews in Clinical and Experimental Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0127724328313815240723044625","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, a meta-analysis was conducted to investigate the therapeutic
effect of Dapagliflozin (DAPA) on animals suffering from myocardial ischemia reperfusion compared to the group that did not receive treatment.
According to the inclusion and exclusion criteria two researchers performed the primary
and secondary screening based on the title abstract and full text. After data extraction, meta-analysis
was performed using STATA software. Standardized mean differences were used to analyze the results of the reported studies. Subgroup analysis and quality control of articles were also conducted
A total of 21 separate experiments showed that DAPA increased mean fractional shortening (%FS) and ejection fraction (%EF) compared to the untreated animals. A significant reduction
in the weight and size of the infarcted area and significant increases in dp/dt+
, dp/dt-
, left ventricular
end-systolic internal dimensions (LVIDs), left ventricular end-diastolic internal dimensions
(LVIDd), Volume systole and Volume diastole were observed in treated animals.
DAPA has the potential to become a candidate for the treatment of post-ischemic heart
damage, pending animal and human studies to validate this.