Studies toward the synthesis of Colletotrichamide A: Construction of C19-C30 Segment of the Molecule

Abstract

The synthesis of C19–C30 segment of the neuroprotective natural product colletotrichamide A has been achieved by performing Sonogashira coupling between the fragments 9 and 10. Maruoka-Keck allylation, Evans syn-aldol and Takai olefinations were used as the key steps for fragment 9 whereas glycosidation and Ohira-Bestmann reactions were used as the pivotal steps for accessing fragment 10.