A review on influenza A virus and relevant drugs

YeeNok Wong
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Abstract

Influenza A virus is a verry common virus around the world, where thousands of people will be infected every month. This is why it is important to have drugs that are responsible for curing influenza A virus. In this review, the article will mainly focus on the synthesis and the binding mechanisms of oseltamivir and amantadine hydrochloride with influenza A virus. Apart from they are both used in curing the infection of Influenza A virus, another similarity of these two drugs is they both have some problems in different aspect. For instance, oseltamivir phosphate has a really complex synthesizing process comparing to most of the drugs we can see in the market. The problem of amantadine hydrochloride is even bigger. It will cause several sever negative effects on the human body including damage on DNA and effects on mitotic cell cycle.
甲型流感病毒及相关药物综述
甲型流感病毒是世界上一种非常常见的病毒,每个月都有成千上万的人受到感染。因此,拥有治疗甲型流感病毒的药物非常重要。在这篇综述中,文章将主要介绍奥司他韦和盐酸金刚烷胺的合成及其与甲型流感病毒的结合机制。除了都用于治疗甲型流感病毒感染外,这两种药物的另一个相似之处在于它们都在不同方面存在一些问题。例如,与我们在市场上看到的大多数药物相比,磷酸奥司他韦的合成过程非常复杂。盐酸金刚烷胺的问题更大。盐酸金刚烷胺会对人体造成多种严重的负面影响,包括对 DNA 的破坏和对有丝分裂细胞周期的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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