Combinatorial approach of cannabidiol and active-targeted-mediated photodynamic therapy in malignant melanoma treatment

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Nkune Williams Nkune, Heidi Abrahamse
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引用次数: 0

Abstract

Malignant melanoma (MM) continues to claim millions of lives around the world due to its limited therapeutic alternatives. Photodynamic therapy (PDT) has gained popularity in cancer treatment due it increased potency and low off-target toxicity. Studies have pointed out that the heterogeneity of MM tumours reduces the efficacy of current therapeutic approaches, including PDT, leading to high chances of recurrences post-treatment. Accumulating evidence suggests that cannabidiol (CBD), a non-psychoactive derivative of cannabis, can synergise with various anticancer agents to increase their efficacy. However, CBD demonstrates low bioavailability, which is attributed to factors relating to poor water compatibility, poor absorption and rapid metabolism. Nanotechnology offers tools that address these issues and enhance the biological efficiency and targeted specificity of anticancer agents. Herein, we highlighted the standard therapeutic modalities of MM and their pitfalls, as well as pointed out the need for further investigation into PDT combination therapy with CBD.

Abstract Image

大麻二酚与活性靶向光动力疗法在恶性黑色素瘤治疗中的组合方法。
由于治疗手段有限,恶性黑色素瘤(MM)仍在夺走全世界数百万人的生命。光动力疗法(PDT)由于效力高、脱靶毒性低,在癌症治疗中越来越受欢迎。研究指出,MM 肿瘤的异质性降低了包括光动力疗法在内的现有治疗方法的疗效,导致治疗后复发的几率很高。越来越多的证据表明,大麻二酚(CBD)是大麻的一种非精神活性衍生物,可与各种抗癌药物协同增效,提高疗效。然而,大麻二酚的生物利用率较低,这归因于与水的相容性差、吸收率低和新陈代谢快等因素。纳米技术提供了解决这些问题的工具,提高了抗癌药物的生物效率和靶向特异性。在此,我们重点介绍了 MM 的标准治疗方法及其缺陷,并指出了进一步研究 PDT 与 CBD 联合疗法的必要性。
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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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