Association among internalizing problems, white matter integrity, and social difficulties in children with autism spectrum disorder

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY
Yu Feng , Xinyue Huang , Weixin Zhao , Yating Ming , Yuanyue Zhou , Rui Feng , Jinming Xiao , Xiaolong Shan , Xiaodong Kang , Xujun Duan , Huafu Chen
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Abstract

Autism spectrum disorder (ASD) is characterized by social difficulties and often accompanied by internalizing and externalizing problems, which are frequently overlooked. Here, we examined and compared fractional anisotropy (FA) between 79 children with ASD (aged 4–7.8 years) and 70 age-, gender-, and handedness- matched typically developing controls (TDCs, aged 3–7.2 years). We aimed to explore the relationship among social difficulties, internalizing and externalizing problems, and brain structural foundation (characterized by white matter integrity). Compared with the TDCs, the children with ASD exhibited more severe internalizing and externalizing problems, which were positively correlated with social difficulties. Reduced FA values were observed in specific white matter tracts that integrate a fronto–temporal–occipital circuit. In particular, the FA values within this circuit were negatively correlated with internalizing problems and SRS-TOTAL scores. Mediation analysis revealed that internalizing problems mediated the relationship between the FA values in the left middle longitudinal fasciculus (L-MdLF) and corpus callosum forceps major (CCM) and social difficulties in children with ASD. These findings contribute to our understanding of social difficulties, internalizing and externalizing problems, and white matter integrity in children with ASD and highlight internalizing problems as a mediator between social difficulties and white matter integrity.

自闭症谱系障碍儿童的内化问题、白质完整性和社交障碍之间的关联。
自闭症谱系障碍(ASD)以社交障碍为特征,通常伴有内化和外化问题,而这些问题经常被忽视。在此,我们研究并比较了 79 名患有自闭症谱系障碍的儿童(4-7.8 岁)与 70 名年龄、性别和手性匹配的典型发育对照组(TDCs,3-7.2 岁)的分数各向异性(FA)。我们旨在探讨社交障碍、内化和外化问题与大脑结构基础(以白质完整性为特征)之间的关系。与TDCs相比,ASD患儿表现出更严重的内化和外化问题,这些问题与社交障碍呈正相关。在整合额颞枕回路的特定白质束中观察到 FA 值降低。特别是,该回路中的 FA 值与内化问题和 SRS-TOTAL 分数呈负相关。中介分析显示,内化问题在左中纵筋束(L-MdLF)和胼胝体大肌(CCM)的FA值与ASD儿童社交障碍之间起中介作用。这些研究结果有助于我们了解ASD儿童的社交障碍、内化和外化问题以及白质完整性,并强调内化问题是社交障碍和白质完整性之间的中介因素。
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来源期刊
CiteScore
12.00
自引率
1.80%
发文量
153
审稿时长
56 days
期刊介绍: Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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