Epilepsia Partialis Continua as a manifestation of aquaporin-4 autoimmunity.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY
Marina Romozzi, Catello Vollono, Paolo Calabresi, Raffaele Iorio
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引用次数: 0

Abstract

A 52-year-old man experienced two seizures in January and June 2021. In October, the neurological examination did not reveal sensory/motor deficits. Brain magnetic resonance imaging (MRI) showed hyperintense lesions with contrast enhancement (CE) involving white matter bilaterally, brainstem, and cerebellum. Spine MRI showed hyperintense C2-C3 and C4-C6 lesions with CE. Anti-aquaporin-4 (AQP4) antibodies were detected, confirming the diagnosis of neuromyelitis optica spectrum disorder (NMOSD). The patient experienced a status epilepticus compatible with Epilepsia Partialis Continua treated with antiseizure medications. He was also treated with methylprednisolone, plasma exchange, and rituximab. Status epilepticus can be a rare manifestation of NMOSD, heightening the broad spectrum of AQP4 autoimmunity.

癫痫部分性持续状态是水蒸发蛋白-4自身免疫的一种表现形式。
一名 52 岁的男子在 2021 年 1 月和 6 月经历了两次癫痫发作。10 月份,神经系统检查未发现感觉/运动障碍。脑磁共振成像(MRI)显示,双侧脑白质、脑干和小脑出现高密度病变,并伴有对比增强(CE)。脊柱核磁共振成像显示,C2-C3和C4-C6病变呈高密度,伴CE。检测到抗quaporin-4(AQP4)抗体,确诊为神经脊髓炎视网膜频谱紊乱症(NMOSD)。患者在接受抗癫痫药物治疗后,出现了与癫痫持续状态(Epilepsia Partialis Continua)相符的癫痫状态。他还接受了甲基强的松龙、血浆置换和利妥昔单抗治疗。癫痫状态可能是 NMOSD 的一种罕见表现,这就增加了 AQP4 自身免疫的广泛性。
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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
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