Lessons learnt from broad-spectrum coronavirus antiviral drug discovery.

IF 6 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Expert Opinion on Drug Discovery Pub Date : 2024-09-01 Epub Date: 2024-07-30 DOI:10.1080/17460441.2024.2385598
Andrew A Bolinger, Jun Li, Xuping Xie, Hongmin Li, Jia Zhou
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引用次数: 0

Abstract

Introduction: Highly pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and the most recent SARS-CoV-2 responsible for the COVID-19 pandemic, pose significant threats to human populations over the past two decades. These CoVs have caused a broad spectrum of clinical manifestations ranging from asymptomatic to severe distress syndromes (ARDS), resulting in high morbidity and mortality.

Areas covered: The accelerated advancements in antiviral drug discovery, spurred by the COVID-19 pandemic, have shed new light on the imperative to develop treatments effective against a broad spectrum of CoVs. This perspective discusses strategies and lessons learnt in targeting viral non-structural proteins, structural proteins, drug repurposing, and combinational approaches for the development of antivirals against CoVs.

Expert opinion: Drawing lessons from the pandemic, it becomes evident that the absence of efficient broad-spectrum antiviral drugs increases the vulnerability of public health systems to the potential onslaught by highly pathogenic CoVs. The rapid and sustained spread of novel CoVs can have devastating consequences without effective and specifically targeted treatments. Prioritizing the effective development of broad-spectrum antivirals is imperative for bolstering the resilience of public health systems and mitigating the potential impact of future highly pathogenic CoVs.

广谱冠状病毒抗病毒药物研发的经验教训。
导言:高致病性冠状病毒(CoVs),如严重急性呼吸系统综合征冠状病毒(SARS-CoV)、中东呼吸系统综合征冠状病毒(MERS-CoV)以及导致 COVID-19 大流行的最新 SARS-CoV-2 在过去二十年中对人类构成了重大威胁。这些 CoV 引起了从无症状到严重窘迫综合征(ARDS)等多种临床表现,导致了高发病率和高死亡率:在 COVID-19 大流行的推动下,抗病毒药物研发取得了突飞猛进的发展,这使人们重新认识到开发有效治疗各种 CoV 的药物势在必行。本视角讨论了针对病毒非结构蛋白、结构蛋白、药物再利用和组合方法开发抗 CoV 抗病毒药物的策略和经验教训:从大流行病中汲取的教训表明,缺乏高效的广谱抗病毒药物会增加公共卫生系统面对高致病性 CoV 潜在攻击的脆弱性。如果没有有效和有针对性的治疗方法,新型 CoV 的快速和持续传播会带来毁灭性后果。优先有效开发广谱抗病毒药物对于增强公共卫生系统的复原力和减轻未来高致病性 CoV 的潜在影响至关重要。
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来源期刊
CiteScore
10.20
自引率
1.60%
发文量
78
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Drug Discovery (ISSN 1746-0441 [print], 1746-045X [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on novel technologies involved in the drug discovery process, leading to new leads and reduced attrition rates. Each article is structured to incorporate the author’s own expert opinion on the scope for future development. The Editors welcome: Reviews covering chemoinformatics; bioinformatics; assay development; novel screening technologies; in vitro/in vivo models; structure-based drug design; systems biology Drug Case Histories examining the steps involved in the preclinical and clinical development of a particular drug The audience consists of scientists and managers in the healthcare and pharmaceutical industry, academic pharmaceutical scientists and other closely related professionals looking to enhance the success of their drug candidates through optimisation at the preclinical level.
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