A clinical case of lymphoma with hindlimb paresis due to mass formation in the spinal canal in a Japanese Black cow.

IF 1.1 4区 农林科学 Q3 VETERINARY SCIENCES
Journal of Veterinary Medical Science Pub Date : 2024-09-10 Epub Date: 2024-07-26 DOI:10.1292/jvms.24-0152
Tatsuki Nagata, Yoshinao Oouchi, Kie Yamamoto, Masaki Maezawa, James K Chambers, Kazuyuki Uchida, Hisashi Inokuma
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引用次数: 0

Abstract

A 5-year-old Japanese Black cow presented with astasia. Bovine leukemia virus (BLV) was detected in the peripheral blood with lower proviral load (PVL). No enlargement of surface lymph nodes or lymphocytosis was observed. Necropsy revealed no enlarged lymph nodes in the thoracic, abdominal, or pelvic cavity. Spinal epidural and peri-medullary adipose tissue was increased in the spinal canal of lumbar to sacral vertebrae, Histopathological examination revealed tumor invasion of the epidural adipose tissue, and a diagnosis of B-cell lymphoma was made. The PVL in tumor tissue was higher, and monoclonal integration of BLV was confirmed. It was a rare case of bovine enzootic leukosis that formed a solitary mass around the spinal cord which might cause hindlimb paresis.

日本黑牛淋巴瘤伴后肢瘫痪的临床病例,病因是椎管内形成肿块。
一头 5 岁的日本黑牛出现哮喘。外周血中检测到牛白血病病毒(BLV),但病毒载量(PVL)较低。未发现体表淋巴结肿大或淋巴细胞增多。尸检显示胸腔、腹腔或盆腔淋巴结未见肿大。腰椎至骶椎的椎管内脊髓硬膜外和髓周脂肪组织增多,组织病理学检查发现肿瘤侵犯硬膜外脂肪组织,诊断为B细胞淋巴瘤。肿瘤组织中的 PVL 较高,证实了 BLV 的单克隆整合。这是一例罕见的牛流行性白血病,在脊髓周围形成单发肿块,可能导致后肢瘫痪。
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来源期刊
Journal of Veterinary Medical Science
Journal of Veterinary Medical Science 农林科学-兽医学
CiteScore
2.30
自引率
8.30%
发文量
230
审稿时长
9-18 weeks
期刊介绍: JVMS is a peer-reviewed journal and publishes a variety of papers on veterinary science from basic research to applied science and clinical research. JVMS is published monthly and consists of twelve issues per year. Papers are from the areas of anatomy, physiology, pharmacology, toxicology, pathology, immunology, microbiology, virology, parasitology, internal medicine, surgery, clinical pathology, theriogenology, avian disease, public health, ethology, and laboratory animal science. Although JVMS has played a role in publishing the scientific achievements of Japanese researchers and clinicians for many years, it now also accepts papers submitted from all over the world.
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