Effect of Chemotherapy on Gonadal Function and Sexual Function of Male Cancer Survivors: A Review Article.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urology Journal Pub Date : 2024-07-29 DOI:10.22037/uj.v21i.8030

Fatemeh Sodeifian, Naghme Kian, Hediyeh Baghsheikhi, Farzad Allameh

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引用次数: 0

Abstract

Introduction: The advancement of anti-cancer treatment has increased survival rates among patients, yet putting them in an increased risk for developing side-effects. In addition to early side-effects, anti-cancer treatments, in particular chemotherapeutic medications can cause long-term side-effects; fertility and sexual dysfunction included. The aim of this study was to review existing data on the effects of different chemotherapeutic agents on fertility and sexual function of male cancer survivors who received chemotherapy at different stages of life.

Method: We searched PubMed/MEDLINE, Scopus, and Google Scholar to detect studies focused on the effect of chemotherapy on the gonadal/testicular function and sexual function of male cancer survivors. We restricted our search to English language publications and manuscript published before the year 2000 were excluded.

Results: It has been well understood that chemotherapy impairs gonadal function in major number of cancer survivors and gonadal dysfunction is not protected if chemotherapeutic agents administered before puberty in males. Moreover, effect of chemotherapy on sexual function is controversial.

Conclusion: While several articles reported the worst effect of chemotherapy on sexual function of cancer survivors, some studied reported that chemotherapy do not impair sexual function. Higher levels of chemotherapy dose seem to be associated with more gonadal and sexual dysfunction.

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化疗对男性癌症幸存者性腺功能和性功能的影响：综述文章。

简介抗癌治疗的进步提高了患者的存活率，但也增加了他们出现副作用的风险。除了早期副作用外，抗癌治疗，尤其是化疗药物，还会导致长期副作用，包括生育和性功能障碍。本研究的目的是回顾不同化疗药物对在不同阶段接受化疗的男性癌症幸存者的生育能力和性功能影响的现有数据：我们检索了 PubMed/MEDLINE、Scopus 和 Google Scholar，以发现有关化疗对男性癌症幸存者性腺/睾丸功能和性功能影响的研究。我们将搜索范围限制在英文出版物上，并排除了 2000 年之前发表的稿件：众所周知，化疗会损害大部分癌症幸存者的性腺功能，而且如果在男性青春期前使用化疗药物，性腺功能障碍也不会得到保护。此外，化疗对性功能的影响也存在争议：结论：虽然有多篇文章报道了化疗对癌症幸存者性功能的最坏影响，但也有一些研究报道化疗不会损害性功能。化疗剂量越大，性腺功能和性功能障碍越多。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.