{"title":"A Comprehensive Review on Liver Regeneration Termination: A Non-Neglectable Phase","authors":"Xiaoguang Chen","doi":"10.3103/s0095452724040030","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>As the most important organ of detoxification in the body, the liver also has the strong regenerative ability itself. The liver can regenerate after partial hepatectomy (PH) and completely restore to its original mass. Liver regeneration (LR) has become one of research hotspots in the field of regenerative biology. Previous basic studies have predominantly concentrated on the initial and proliferative phases of regenerative response, while a relatively little attention has been paid to the mechanism of proper termination of liver regeneration. In recent years, along with the increasing recognition of the significance of LR termination, the growing researches have been carried out and some achievement has been made in a certain extent. The successful completion of LR is considered to involve many cells, growth factors, signaling pathways, metabolites and other extrahepatic factors. This article will review the progression of research on the mechanism of LR termination after PH in recent years.</p>","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3103/s0095452724040030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
As the most important organ of detoxification in the body, the liver also has the strong regenerative ability itself. The liver can regenerate after partial hepatectomy (PH) and completely restore to its original mass. Liver regeneration (LR) has become one of research hotspots in the field of regenerative biology. Previous basic studies have predominantly concentrated on the initial and proliferative phases of regenerative response, while a relatively little attention has been paid to the mechanism of proper termination of liver regeneration. In recent years, along with the increasing recognition of the significance of LR termination, the growing researches have been carried out and some achievement has been made in a certain extent. The successful completion of LR is considered to involve many cells, growth factors, signaling pathways, metabolites and other extrahepatic factors. This article will review the progression of research on the mechanism of LR termination after PH in recent years.
摘要 作为人体最重要的解毒器官，肝脏本身也具有很强的再生能力。肝脏部分切除（PH）后可以再生，并完全恢复到原来的质量。肝脏再生（LR）已成为再生生物学领域的研究热点之一。以往的基础研究主要集中在再生反应的初始阶段和增殖阶段，而对肝脏再生正常终止机制的关注相对较少。近年来，随着人们对 LR 终止重要性的认识不断提高，相关研究也在不断深入，并取得了一定的成果。LR 的成功完成涉及多种细胞、生长因子、信号通路、代谢产物和其他肝外因素。本文将综述近年来关于 PH 后 LR 终止机制的研究进展。
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