Characterization of cells and mediators associated with pruritus in primary cutaneous T-cell lymphomas

IF 3.2 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Man Hu, Jörg Scheffel, Stefan Frischbutter, Carolin Steinert, Ulrich Reidel, Max Spindler, Katarzyna Przybyłowicz, Marlena Hawro, Marcus Maurer, Martin Metz, Tomasz Hawro
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引用次数: 0

Abstract

Patients with primary cutaneous T-cell lymphoma (CTCL) often experience severe and difficult-to-treat pruritus that negatively affects their quality of life (QoL). However, the mechanisms of pruritus in CTCL, including mycosis fungoides (MF), remain largely unknown, and detailed characteristics of CTCL-associated pruritus is not fully elucidated. To characterize pruritus in CTCL, cutaneous B-cell lymphoma (CBCL), and large plaque parapsoriasis (LPP), and to identify potential itch mediators involved in the pathogenesis of pruritus in CTCL patients. Clinical data and blood samples were collected from 129 healthy subjects and 142 patients. Itch intensity, QoL impairment, psychological distress, and sleep quality were assessed using validated questionnaires and instruments. Blood levels of BDNF, CCL24, GRP, IL-31, IL-33, sST2, substance P, TSLP, tryptase and total IgE were measured using ELISA or ImmunoCAP. Pruritus was prevalent in CTCL, LPP and CBCL patients, with higher prevalence and severity observed in CTCL. In CTCL, pruritus correlated with significant impairment in QoL, sleep, psychological distress. Compared to healthy controls, elevated levels of IL-31, IL-33, substance P, total IgE, tryptase, and TSLP were found in MF patients. A comparison of MF patients with and without pruritus revealed higher levels of IL-31, substance P, GRP, and CCL24 in the former. Itch intensity positively correlated with IL-31, GRP, CCL24, and tryptase levels. Pruritus significantly burdens CTCL patients, necessitating appropriate therapeutic management. Our findings suggest that various non-histaminergic mediators such as tryptase and IL-31 could be explored as novel therapeutic targets for managing pruritus in MF patients.

Abstract Image

与原发性皮肤 T 细胞淋巴瘤瘙痒症相关的细胞和介质的特征
原发性皮肤T细胞淋巴瘤(CTCL)患者经常会出现严重且难以治疗的瘙痒症状,这对他们的生活质量(QoL)造成了负面影响。然而,包括真菌病(MF)在内的CTCL瘙痒症的发病机制在很大程度上仍不为人所知,CTCL相关瘙痒症的详细特征也未完全阐明。为了描述CTCL、皮肤B细胞淋巴瘤(CBCL)和大斑块副银屑病(LPP)的瘙痒特征,并确定参与CTCL患者瘙痒发病机制的潜在瘙痒介质。研究收集了 129 名健康受试者和 142 名患者的临床数据和血液样本。使用经过验证的问卷和工具对瘙痒强度、QoL损害、心理困扰和睡眠质量进行了评估。使用 ELISA 或 ImmunoCAP 测量了血液中 BDNF、CCL24、GRP、IL-31、IL-33、sST2、P 物质、TSLP、胰蛋白酶和总 IgE 的水平。瘙痒在 CTCL、LPP 和 CBCL 患者中普遍存在,CTCL 患者的瘙痒发生率和严重程度更高。在CTCL患者中,瘙痒与患者的生活质量、睡眠和心理压力明显相关。与健康对照组相比,MF 患者的 IL-31、IL-33、P 物质、总 IgE、胰蛋白酶和 TSLP 水平升高。对有瘙痒症和无瘙痒症的手足口病患者进行比较后发现,前者的 IL-31、P 物质、GRP 和 CCL24 水平更高。瘙痒强度与 IL-31、GRP、CCL24 和胰蛋白酶水平呈正相关。瘙痒给 CTCL 患者带来了沉重负担,因此必须采取适当的治疗措施。我们的研究结果表明,胰蛋白酶和IL-31等各种非组胺能介质可作为治疗中风患者瘙痒症的新靶点。
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来源期刊
Clinical and Experimental Medicine
Clinical and Experimental Medicine 医学-医学:研究与实验
CiteScore
4.80
自引率
2.20%
发文量
159
审稿时长
2.5 months
期刊介绍: Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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