EPR Study of Controlled Drug Release from PNIPAM and P(NIPAM-g-PLA) Globules

IF 1.4 4区化学 Q4 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

Russian Journal of Physical Chemistry B Pub Date : 2024-07-22 DOI:10.1134/s1990793124700180

T. A. Ivanova, E. M. Zubanova, P. S. Timashev, E. N. Golubeva

引用次数: 0

Abstract

Spin probe electron paramagnetic resonance spectroscopy was applied to estimate release kinetic patterns from globules formed in solutions of thermoresponsive polymers poly-N-isopropylacrylamide (PNIPAM) and graft copolymer based on N-isopropylacrylamide and oligolactide (P(NIPAM-g-PLA)) containing (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) spin probe as a drug model. It is shown that the main mechanism of TEMPO release from globules of thermoresponsive polymers in aqueous solutions above LSCT is Brownian diffusion.

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PNIPAM 和 P(NIPAM-g-PLA)胶球中可控药物释放的 EPR 研究

摘要应用旋转探针电子顺磁共振波谱估算了热致伸缩性聚合物聚-N-异丙基丙烯酰胺（PNIPAM）和基于N-异丙基丙烯酰胺和低聚乳内酯的接枝共聚物（P(NIPAM-g-PLA)）溶液中形成的球状物的释放动力学模式，球状物中含有（2,2,6,6-四甲基哌啶-1-基）氧自由基（TEMPO）旋转探针作为药物模型。研究表明，TEMPO 在 LSCT 以上的水溶液中从热致伸缩性聚合物球中释放的主要机制是布朗扩散。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of Physical Chemistry B 化学-物理：原子、分子和化学物理

CiteScore

2.20

自引率

71.40%

发文量

106

审稿时长

4-8 weeks

期刊介绍： Russian Journal of Physical Chemistry B: Focus on Physics is a journal that publishes studies in the following areas: elementary physical and chemical processes; structure of chemical compounds, reactivity, effect of external field and environment on chemical transformations; molecular dynamics and molecular organization; dynamics and kinetics of photoand radiation-induced processes; mechanism of chemical reactions in gas and condensed phases and at interfaces; chain and thermal processes of ignition, combustion and detonation in gases, two-phase and condensed systems; shock waves; new physical methods of examining chemical reactions; and biological processes in chemical physics.