M. A. Shkurat, E. V. Mashkina, N. P. Milyutina, E. D. Teplyakova, T. P. Shkurat
{"title":"Polymorphism of Antioxidant Genes and Overweight in Children","authors":"M. A. Shkurat, E. V. Mashkina, N. P. Milyutina, E. D. Teplyakova, T. P. Shkurat","doi":"10.1134/s102279542470039x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">\n<b>Abstract</b>—</h3><p>Oxidative stress is one of the components of the pathological process leading to the development of obesity. The level of formation of free radical products is controlled by the antioxidant system. Antioxidant gene polymorphism influences the level and/or activity of the encoded enzymes. The purpose of this work was to investigate the association of SNP in the genes of the antioxidant system with the risk of overweight in children and adolescents. The material for the study were DNA samples from 279 overweight children and 131 children from the control group. Genotyping was performed for rs6721961 (<i>–617G>T</i>) <i>NFE2L2</i>, rs4998557 (<i>7958G>A</i>) <i>SOD1</i>, rs4880 (<i>47C>T Ala16Val</i>) <i>SOD2</i>, rs1001179 (<i>–262C>T</i>) <i>CAT</i>, rs713041 (<i>718C>T</i>) <i>GPX4</i>, rs662 (<i>Gln192Arg</i>) <i>PON1</i>. It has been shown that the –<i>617GT</i> genotype (rs6721961) <i>NFE2L2</i> is associated with a decreased risk of overweight in children. An increased risk of developing overweight was detected for heterozygotes –<i>262CT</i> for rs1001179 <i>CAT</i> and the –<i>262T</i> allele. As a result of the analysis of intergenic interactions, a 6-locus genotype was identified that is associated with a reduced risk of overweight.</p>","PeriodicalId":21441,"journal":{"name":"Russian Journal of Genetics","volume":"1 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s102279542470039x","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract—
Oxidative stress is one of the components of the pathological process leading to the development of obesity. The level of formation of free radical products is controlled by the antioxidant system. Antioxidant gene polymorphism influences the level and/or activity of the encoded enzymes. The purpose of this work was to investigate the association of SNP in the genes of the antioxidant system with the risk of overweight in children and adolescents. The material for the study were DNA samples from 279 overweight children and 131 children from the control group. Genotyping was performed for rs6721961 (–617G>T) NFE2L2, rs4998557 (7958G>A) SOD1, rs4880 (47C>T Ala16Val) SOD2, rs1001179 (–262C>T) CAT, rs713041 (718C>T) GPX4, rs662 (Gln192Arg) PON1. It has been shown that the –617GT genotype (rs6721961) NFE2L2 is associated with a decreased risk of overweight in children. An increased risk of developing overweight was detected for heterozygotes –262CT for rs1001179 CAT and the –262T allele. As a result of the analysis of intergenic interactions, a 6-locus genotype was identified that is associated with a reduced risk of overweight.
期刊介绍：
Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.
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