Optimizing Antifungal Treatment Strategies to Prevent Invasive Pulmonary Aspergillosis Infection-Related Deaths in Intensive Care Unit Patients: The Need for Standardization of Research Definitions

IF 3.6 3区生物学 Q2 MYCOLOGY

Mycopathologia Pub Date : 2024-07-27 DOI:10.1007/s11046-024-00879-6

Matteo Bassetti, Antonio Vena, Martina Bavastro, Daniele Roberto Giacobbe

引用次数: 0

Abstract

The clinical spectrum of invasive pulmonary aspergillosis (IPA) has expanded in recent decades. A large group of patients admitted to intensive care units (ICU) is indeed susceptible to the development of IPA. Although timely diagnosis and antifungal therapy of IPA in this expanding population is crucial to prevent IPA-related deaths, the magnitude of the favorable prognostic impact of antifungal therapy is difficult to measure precisely. In our opinion, the development of standardized research definitions could have favorable implications for further improving our ability both to measure the favorable effect of antifungal treatment and to prevent IPA-related death in ICU patients.

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优化抗真菌治疗策略，预防重症监护病房患者因侵袭性肺曲霉菌病感染而死亡：研究定义标准化的必要性

近几十年来，侵袭性肺曲霉菌病（IPA）的临床范围不断扩大。入住重症监护病房（ICU）的一大批患者确实很容易患上 IPA。尽管在这一不断扩大的人群中及时诊断和抗真菌治疗对于防止与 IPA 相关的死亡至关重要，但抗真菌治疗对预后的有利影响程度却很难精确测量。我们认为，制定标准化的研究定义将对进一步提高我们衡量抗真菌治疗的有利影响和预防 ICU 患者 IPA 相关死亡的能力产生有利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mycopathologia 生物-真菌学

CiteScore

6.80

自引率

3.60%

发文量

审稿时长

3 months

期刊介绍： Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.

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