Cognitive ability, education, height and body mass index in relation to risk of schizophrenia and mortality following its diagnosis

IF 7.7 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Terese Sara Høj Jørgensen, Ida Kim Wium-Andersen, Marie Kim Wium-Andersen, Maarten Pieter Rozing, Martin Balslev Jørgensen, Thorkild IA Sørensen, Merete Osler
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Abstract

This study examines the hypotheses that the traits of higher IQ, longer education and taller height are associated with lower risk of death as compared to traits of low IQ, short education, and short height in men with schizophrenia compared to men without schizophrenia. In total, 937,919 men born 1939-59 and 1983–1997 with information from conscription were followed for incident schizophrenia in Danish registries. Higher levels of cognitive ability, longer education, and taller height were associated with fewer cases of schizophrenia. In a sub-sample of 652,368 men with information on body mass index, underweight was associated with more and overweight and obesity were associated with fewer cases of schizophrenia compared with normal weight. Higher cognitive ability, longer education, and taller height were associated with fewer deaths from both natural and unnatural causes in both men with and without schizophrenia. Underweight was associated with more deaths from natural and unnatural causes, whereas overweight and obesity were associated with more deaths from natural causes and fewer deaths from unnatural causes in both groups of men. Due to interaction, tall height and long educational duration were associated with fewer deaths from natural causes, and obesity was associated with fewer deaths from unnatural causes among men with schizophrenia compared to men without. In conclusion, traits in young adulthood are associated with higher mortality in men with and without schizophrenia, but traits of long educational duration and obesity seem to be especially important for lower mortality in men with schizophrenia.

Abstract Image

认知能力、教育程度、身高和体重指数与精神分裂症风险和确诊后死亡率的关系
与未患精神分裂症的男性相比,患精神分裂症的男性智商较高、受教育时间较长、身高较高的特征与智商较低、受教育时间较短、身高较矮的特征相比与死亡风险较低的特征相关,本研究探讨了这一假设。丹麦登记处共对 937,919 名出生于 1939-59 年和 1983-1997 年、有征兵信息的男性精神分裂症患者进行了跟踪调查。认知能力越高、受教育时间越长、身高越高的人患精神分裂症的病例越少。在有体重指数信息的 652,368 名男性子样本中,与正常体重相比,体重不足与更多精神分裂症病例有关,而超重和肥胖与更少的精神分裂症病例有关。在患有和未患有精神分裂症的男性中,较高的认知能力、较长的受教育时间和较高的身高与较少的自然和非自然死亡有关。在两组男性中,体重不足与更多的自然死亡和非自然死亡有关,而超重和肥胖与更多的自然死亡和更少的非自然死亡有关。由于相互作用,与非精神分裂症男性相比,身高和受教育时间长与较少的自然死亡有关,而肥胖与较少的非自然死亡有关。总之,在患有和未患有精神分裂症的男性中,年轻时的特征与较高的死亡率有关,但受教育时间长和肥胖的特征似乎对降低精神分裂症男性的死亡率尤为重要。
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来源期刊
European Journal of Epidemiology
European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
21.40
自引率
1.50%
发文量
109
审稿时长
6-12 weeks
期刊介绍: The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.
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