Emergence and properties of adult mammalian epidermal stem cells

IF 2.5 3区生物学 Q2 DEVELOPMENTAL BIOLOGY

Developmental biology Pub Date : 2024-07-24 DOI:10.1016/j.ydbio.2024.07.014

Purna Gadre, Pavlina Markova, Mirsana Ebrahimkutty, Yidan Jiang, Francisco M. Bouzada, Fiona M. Watt

引用次数: 0

Abstract

In this review we discuss how the mammalian interfollicular epidermis forms during development, maintains homeostasis, and is repaired following wounding. Recent studies have provided new insights into the relationship between the stem cell compartment and the differentiating cell layers; the ability of differentiated cells to dedifferentiate into stem cells; and the epigenetic memory of epidermal cells following wounding.

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成年哺乳动物表皮干细胞的出现和特性。

在这篇综述中，我们将讨论哺乳动物角质层间表皮是如何在发育过程中形成、保持平衡以及在受伤后修复的。最近的研究为干细胞区与分化细胞层之间的关系、分化细胞向干细胞再分化的能力以及表皮细胞在受伤后的表观遗传记忆提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental biology 生物-发育生物学

CiteScore

5.30

自引率

3.70%

发文量

182

审稿时长

1.5 months

期刊介绍： Developmental Biology (DB) publishes original research on mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning, cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals.