Prevalence of opioid misuse in patients with cancer: a systematic review and meta-analysis

IF 6.4 1区医学 Q1 ONCOLOGY

British Journal of Cancer Pub Date : 2024-07-26 DOI:10.1038/s41416-024-02802-8

Tazha Ako, Mark Puch Ørnskov, Camilla Lykke, Per Sjøgren, Geana Paula Kurita

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Abstract

Long-term consequences of opioid consumption, such as misuse, have been a major concern in patients with chronic non-cancer pain. Potentially opioid misuse may also be a consequence in patients with cancer in opioid treatment which encouraged us to undertake this systematic review assessing the frequency of opioid misuse in this population. The search strategy comprised words related to cancer, opioid misuse, and frequency. PubMed, Embase, PsycInfo, and Cinahl were searched from inception to July 2023. Prospective studies were selected and analysed regarding frequency, study characteristics, and quality. A meta-analysis was possible to carry out for a sub-group (opioid misuse risk). From 585 abstracts screened, six articles were included. Only prevalence data were found. The prevalence of opioid misuse ranged from 5.7% to 84%, while the prevalence of opioid misuse risk varied from 2.4% to 35.4%. The pooled prevalence of opioid misuse risk was 12.3% (95% CI: 0.8–36.3; I2 = 98.4%, 95% CI: 97.2–99.1). The studies differed regarding, e.g., methods, misuse definitions, and assessment instruments. Few studies were identified and large differences in prevalence for opioid misuse and opioid misuse risk were observed. Methodological disparities and the studies quality underscore the importance of improved studies in the future.

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癌症患者滥用阿片类药物的普遍性：系统回顾和荟萃分析。

背景/目的：滥用阿片类药物等阿片类药物消费的长期后果一直是慢性非癌症疼痛患者关注的主要问题。在接受阿片类药物治疗的癌症患者中，阿片类药物滥用可能也是一个后果，这促使我们开展了这项系统性综述，评估这一人群中阿片类药物滥用的频率：搜索策略包括与癌症、阿片类药物滥用和频率相关的词汇。对 PubMed、Embase、PsycInfo 和 Cinahl 从开始到 2023 年 7 月进行了检索。筛选出了前瞻性研究，并对研究频率、研究特点和质量进行了分析。对一个分组（阿片类药物滥用风险）进行了荟萃分析：结果：从筛选出的 585 篇摘要中，共收录了 6 篇文章。仅发现了流行率数据。阿片类药物滥用的流行率从 5.7% 到 84% 不等，而阿片类药物滥用风险的流行率从 2.4% 到 35.4% 不等。阿片类药物滥用风险的总体流行率为 12.3%（95% CI：0.8-36.3；I2 = 98.4%，95% CI：97.2-99.1）。这些研究在方法、滥用定义和评估工具等方面存在差异：结论：所发现的研究很少，但观察到阿片类药物滥用和阿片类药物滥用风险的流行率存在很大差异。方法上的差异和研究质量强调了今后改进研究的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Cancer 医学-肿瘤学

CiteScore

15.10

自引率

1.10%

发文量

383

审稿时长

6 months

期刊介绍： The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.