Tubarial salivary glands show a low relative contribution to functional salivary gland tissue mass

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Sui wai Ling, Astrid van der Veldt, Marcel Segbers, Henk Luiting, Tessa Brabander, Frederik Verburg
{"title":"Tubarial salivary glands show a low relative contribution to functional salivary gland tissue mass","authors":"Sui wai Ling,&nbsp;Astrid van der Veldt,&nbsp;Marcel Segbers,&nbsp;Henk Luiting,&nbsp;Tessa Brabander,&nbsp;Frederik Verburg","doi":"10.1007/s12149-024-01965-x","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>In 2021, the tubarial salivary glands (TSGs) were newly identified on prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) as macroscopic glands in the nasopharyngeal wall. However, the relative contribution of the TSGs to the total salivary gland function, and consequently on the development of xerostomia after external beam radiotherapy (EBRT) or PSMA-targeted radionuclide therapy (RNT) is not known. Therefore, we aimed to determine the presence of the TSGs and to quantify uptake in the TSGs on PSMA PET.</p><h3>Methods</h3><p>Qualitative and quantitative analyses were performed on <sup>68</sup>Ga-PSMA-11 PET/CT scans of 100 patients with prostate cancer. The mean and maximum standardized uptake value (SUVmean and SUVmax) in the TSGs were measured and compared to the parotid, submandibular and sublingual salivary glands (PSGs, SMSGs and SLSGs, respectively). Furthermore, proportional function of the TSGs was compared to the PSGs, SMSGs and SLSGs based on the total organ PSMA (TO-PSMA).</p><h3>Results</h3><p>The TSGs were visible on 95% of the <sup>68</sup>Ga-PSMA-11 PET/CT scans. The normalized median SUVmean and SUVmax was significantly higher for the PSGs (<i>p</i> &lt; 0.001) and SMSGs (<i>p</i> &lt; 0.001) compared to the TSGs, but not for the SLSGs (<i>p</i> = 0.242 and <i>p</i> = 0.300, respectively). The normalized median TO-PSMA was significantly higher for the PSGs (<i>p</i> &lt; 0.001) and SMSGs (<i>p</i> &lt; 0.001), and significant lower for the SLSGs (<i>p</i> &lt; 0.001) compared the TSGs.</p><h3>Conclusions</h3><p>The SUVmean, SUVmax and TO-PSMA of the TSGs were most comparable to the SLSGs. However, the measured PSMA uptake may be disproportional towards the saliva production. Therefore, future studies should focus on the relation between PSMA uptake and salivary function before and after PSMA therapy.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 11","pages":"913 - 918"},"PeriodicalIF":2.5000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01965-x.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12149-024-01965-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Background

In 2021, the tubarial salivary glands (TSGs) were newly identified on prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) as macroscopic glands in the nasopharyngeal wall. However, the relative contribution of the TSGs to the total salivary gland function, and consequently on the development of xerostomia after external beam radiotherapy (EBRT) or PSMA-targeted radionuclide therapy (RNT) is not known. Therefore, we aimed to determine the presence of the TSGs and to quantify uptake in the TSGs on PSMA PET.

Methods

Qualitative and quantitative analyses were performed on 68Ga-PSMA-11 PET/CT scans of 100 patients with prostate cancer. The mean and maximum standardized uptake value (SUVmean and SUVmax) in the TSGs were measured and compared to the parotid, submandibular and sublingual salivary glands (PSGs, SMSGs and SLSGs, respectively). Furthermore, proportional function of the TSGs was compared to the PSGs, SMSGs and SLSGs based on the total organ PSMA (TO-PSMA).

Results

The TSGs were visible on 95% of the 68Ga-PSMA-11 PET/CT scans. The normalized median SUVmean and SUVmax was significantly higher for the PSGs (p < 0.001) and SMSGs (p < 0.001) compared to the TSGs, but not for the SLSGs (p = 0.242 and p = 0.300, respectively). The normalized median TO-PSMA was significantly higher for the PSGs (p < 0.001) and SMSGs (p < 0.001), and significant lower for the SLSGs (p < 0.001) compared the TSGs.

Conclusions

The SUVmean, SUVmax and TO-PSMA of the TSGs were most comparable to the SLSGs. However, the measured PSMA uptake may be disproportional towards the saliva production. Therefore, future studies should focus on the relation between PSMA uptake and salivary function before and after PSMA therapy.

Abstract Image

管状唾液腺对功能性唾液腺组织质量的相对贡献率较低。
背景:2021年,前列腺特异性膜抗原(PSMA)正电子发射断层扫描/计算机断层扫描(PET/CT)新发现管状唾液腺(TSGs)是鼻咽壁上的大腺体。然而,TSGs 对唾液腺总功能的相对贡献,以及由此对体外放射治疗(EBRT)或 PSMA 靶向放射性核素治疗(RNT)后发生口干症的影响尚不清楚。因此,我们旨在确定 TSG 的存在,并通过 PSMA PET 对 TSG 的摄取进行量化:方法:我们对 100 名前列腺癌患者的 68Ga-PSMA-11 PET/CT 扫描结果进行了定性和定量分析。测量了 TSG 的平均和最大标准化摄取值(SUVmean 和 SUVmax),并与腮腺、颌下腺和舌下唾液腺(分别为 PSG、SMSG 和 SLSG)进行了比较。此外,还根据器官 PSMA 总量(TO-PSMA)比较了 TSG 与 PSG、SMSG 和 SLSG 的比例功能:结果:95%的68Ga-PSMA-11 PET/CT扫描可见TSG。PSGs 的归一化中位 SUVmean 和 SUVmax 明显更高(p 结论:TSGs 的归一化中位 SUVmean 和 SUVmax 明显更高(p 结论:TSGs 的归一化中位 SUVmean 和 SUVmax 明显更高(pTSGs的SUVmean、SUVmax和TO-PSMA与SLSGs最为相似。然而,测得的 PSMA 摄取可能与唾液分泌不成比例。因此,未来的研究应重点关注 PSMA 治疗前后 PSMA 摄取量与唾液功能之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信