Mechanobiological optimization of scaffolds for bone tissue engineering

IF 3 3区医学 Q2 BIOPHYSICS

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-07-26 DOI:10.1007/s10237-024-01880-0

Timothy O. Josephson, Elise F. Morgan

引用次数: 0

Abstract

Synthetic bone graft scaffolds aim to generate new bone tissue and alleviate the limitations of autografts and allografts. To meet that aim, it is essential to have a design approach able to generate scaffold architectures that will promote bone formation. Here, we present a topology-varying design optimization method, the “mixed-topology” approach, that generates new designs from a set of starting structures. This approach was used with objective functions focusing on improving the scaffold’s local mechanical microenvironments to mechanobiologically promote bone formation within the scaffold and constraints to ensure manufacturability and achieve desired macroscale properties. The results demonstrate that this approach can successfully generate scaffold designs with improved microenvironments, taking into account different combinations of relevant stimuli and constraints.

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骨组织工程支架的机械生物学优化。

合成骨移植支架旨在生成新的骨组织，缓解自体移植和异体移植的局限性。要实现这一目标，必须有一种设计方法能够生成促进骨形成的支架结构。在这里，我们提出了一种拓扑变化设计优化方法，即 "混合拓扑 "方法，它能从一组起始结构中生成新的设计。这种方法的目标函数侧重于改善支架的局部机械微环境，以机械生物学的方式促进支架内的骨形成，同时也有一些约束条件，以确保可制造性并实现所需的宏观特性。结果表明，考虑到相关刺激和约束条件的不同组合，这种方法可以成功生成具有更好微环境的支架设计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomechanics and Modeling in Mechanobiology 工程技术-工程：生物医学

CiteScore

7.10

自引率

8.60%

发文量

119

审稿时长

6 months

期刊介绍： Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.