Elevated Hepatitis B virus RNA levels in hepatocellular carcinoma patients compared to cirrhotic individuals: A propensity score matched analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI:10.4103/sjg.sjg_16_24

Yuying Wang, Juanli Wu, Yushuang Zhang, Lei Wang, Tao Li

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引用次数: 0

Abstract

Background: To delineate the levels of serum Hepatitis B virus (HBV) RNA in patients with HBV-related hepatocellular carcinoma (HCC) and study comparisons with those of individuals afflicted with cirrhosis.

Methods: Adult patients diagnosed with HBV-related cirrhosis or HCC (initial diagnosis) were enrolled in the cross-sectional study. Serum HBV DNA level was quantified through a real-time polymerase chain reaction assay with a lower limit of quantification (LLQ) of 20 IU/ml. Additionally, serum HBV RNA was quantified employing RNA real-time fluorescence thermostatic amplification detection technology with LLQ of 100 copies/ml. Propensity score matching (PSM) was conducted to ensure balance in between-group confounders.

Results: A total of 187 patients (47 with HCC and 140 with cirrhosis) were recruited, among whom 140 (74.9%) had undergone antiviral therapy prior to their inclusion, with varying durations. Serum HBV RNA was detectable in 89.4% of HCC patients at the time of carcinoma diagnosis. After PSM, individuals with HCC exhibited significantly elevated levels of serum HBV DNA and HBV RNA compared to those with cirrhosis (median lgHBV RNA 3.1 vs 2.0 copies/ml, P = 0.001). Subgroup analysis, including 38 patients who exhibited ultrasensitive HBV DNA negativity, revealed similar results (median lgHBV RNA 3.0 vs 0.0 copies/ml, P < 0.001).

Conclusions: Serum HBV RNA levels were significantly higher in HBV-related HCC patients compared to cirrhotic patients. The presence of serum HBV RNA positivity or elevated levels was associated with the onset of HCC.

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与肝硬化患者相比，肝细胞癌患者体内乙型肝炎病毒 RNA 水平升高：倾向得分匹配分析

背景：目的：确定与 HBV 相关的肝细胞癌（HCC）患者的血清乙型肝炎病毒（HBV）RNA 水平，并将其与肝硬化患者进行比较：这项横断面研究招募了被诊断为 HBV 相关肝硬化或 HCC（初次诊断）的成人患者。血清 HBV DNA 水平通过实时聚合酶链反应测定法进行定量，定量下限（LLQ）为 20 IU/ml。此外，血清 HBV RNA 采用 RNA 实时荧光恒温扩增检测技术进行定量，定量下限为 100 拷贝/毫升。进行倾向评分匹配（PSM）以确保组间混杂因素的平衡：共招募了 187 名患者（47 名 HCC 患者和 140 名肝硬化患者），其中 140 人（74.9%）在入组前接受过抗病毒治疗，治疗时间长短不一。89.4% 的 HCC 患者在确诊为癌症时可检测到血清 HBV RNA。PSM 后，与肝硬化患者相比，HCC 患者的血清 HBV DNA 和 HBV RNA 水平明显升高（lgHBV RNA 中位数为 3.1 vs 2.0 copies/ml，P = 0.001）。包括38名HBV DNA超敏阴性患者在内的亚组分析显示了相似的结果（lgHBV RNA中位数为3.0 vs 0.0拷贝/毫升，P < 0.001）：结论：与肝硬化患者相比，HBV 相关 HCC 患者的血清 HBV RNA 水平明显更高。血清 HBV RNA 阳性或水平升高与 HCC 的发病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.