In Vitro Study of Tensile Strength Comparison of Selected Nonabsorbable and Absorbable Suture Materials after Immersion in 0.12% Chlorhexidine Gluconate.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-27 eCollection Date: 2024-05-01 DOI:10.4103/jispcd.jispcd_162_23

Ezra Emmanuel B Ching, Teeranut Chaiyasamut, Chakorn Vorakulpipat

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引用次数: 0

Abstract

Aim: To compare the tensile strength (TS) of absorbable and nonabsorbable suture materials after immersion in 0.12% chlorhexidine gluconate.

Materials and methods: Six 4-0-gauge suture materials were used, namely silk (S), polypropylene (PP), polyamide 6 (PA6), polyglactin 910 (PG910), poliglecaprone 25 (PL25), and polydioxanone (PDX). A total of 540 suture materials were divided equally (90) into six groups and tested. These materials were divided into a nonimmersed condition (10) and two thermostatically controlled immersion media (40 each), using artificial saliva for the control group (CG) and 0.12% chlorhexidine gluconate for the test group (TG). The specimens were tied to prefabricated rubber rods before immersion and removed at the testing timepoint. By using a universal testing machine (Instron 5566) with hooks attached, a hook-mounted specimen TS testing was performed on days 0, 1, 3, 7, and 14 at a 10 mm/min crosshead speed until the material was stretched to failure, and the maximum TS was recorded in Newtons (N). The continuous variables were taken as the mean and standard deviation across the six study groups to assess the significance at α = 0.05. A two-factor analysis of variance (ANOVA) was performed to assess the TSs over time in different media. A Bonferroni correction was performed when the data were statistically significant according to a two-factor ANOVA. Intragroup statistical comparisons were performed by repeated ANOVA for each study group. All data were analyzed using SPSS 26.

Results: The suture material TS analysis showed that nonabsorbable suture materials maintained their TS throughout the study; silk exhibited different behaviors, decreasing in TS from baseline to day 1 and maintaining its TS until day 14. All absorbable suture materials decreased in TSs by day 14. The silk and PG910 samples in the TG performed significantly better than those in the CG.

Conclusions: Prescribing 0.12% chlorhexidine gluconate as a postsurgical mouth rinse is safest when silk and PG910 are the optimal suture materials.

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选定的不可吸收和可吸收缝合材料在 0.12% 洗必泰葡萄糖酸盐中浸泡后的拉伸强度比较体外研究。

目的：比较可吸收和不可吸收缝合材料在 0.12% 洗必泰葡萄糖酸盐中浸泡后的拉伸强度（TS）：使用了六种 4-0 号缝合材料，即蚕丝 (S)、聚丙烯 (PP)、聚酰胺 6 (PA6)、聚乳酸 910 (PG910)、聚乙二醇卡波隆 25 (PL25) 和聚二氧杂蒽酮 (PDX)。总共 540 种缝合材料被平均分成六组（90 种）进行测试。这些材料分为非浸泡状态（10 种）和两种恒温控制浸泡介质（各 40 种），对照组（CG）使用人工唾液，测试组（TG）使用 0.12% 的葡萄糖酸氯己定。浸泡前将试样绑在预制橡胶棒上，并在测试时间点取下。使用带挂钩的万能试验机（Instron 5566），在第 0、1、3、7 和 14 天以 10 毫米/分钟的十字头速度对挂钩试样进行 TS 测试，直到材料拉伸至破坏为止，并以牛顿（N）为单位记录最大 TS 值。连续变量取六个研究组的平均值和标准偏差，在 α = 0.05 时进行显著性评估。采用双因素方差分析（ANOVA）来评估不同介质中不同时间的 TSs。当双因素方差分析得出的数据具有统计学意义时，进行 Bonferroni 校正。各研究组的组内统计比较通过重复方差分析进行。所有数据均使用 SPSS 26 进行分析：缝合材料 TS 分析表明，非吸收性缝合材料在整个研究期间保持其 TS；蚕丝表现出不同的行为，从基线到第 1 天，其 TS 一直在下降，直到第 14 天。所有可吸收缝合材料的 TS 在第 14 天前都有所下降。TG中的蚕丝和PG910样本的表现明显优于CG中的样本：结论：当丝线和 PG910 是最佳缝合材料时，将 0.12% 的葡萄糖酸氯己定作为术后漱口剂是最安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.