Orchestrated centers for the production of proteins or "translation factories".

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Robert A Crawford, Matthew Eastham, Martin R Pool, Mark P Ashe
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引用次数: 0

Abstract

The mechanics of how proteins are generated from mRNA is increasingly well understood. However, much less is known about how protein production is coordinated and orchestrated within the crowded intracellular environment, especially in eukaryotic cells. Recent studies suggest that localized sites exist for the coordinated production of specific proteins. These sites have been termed "translation factories" and roles in protein complex formation, protein localization, inheritance, and translation regulation have been postulated. In this article, we review the evidence supporting the translation of mRNA at these sites, the details of their mechanism of formation, and their likely functional significance. Finally, we consider the key uncertainties regarding these elusive structures in cells. This article is categorized under: Translation Translation > Mechanisms RNA Export and Localization > RNA Localization Translation > Regulation.

精心策划的蛋白质生产中心或 "翻译工厂"。
人们对蛋白质如何从 mRNA 生成的机理有了越来越深入的了解。然而,人们对蛋白质是如何在拥挤的细胞内环境中协调生成的却知之甚少,尤其是在真核细胞中。最近的研究表明,存在着协调生产特定蛋白质的局部位点。这些位点被称为 "翻译工厂",并被推测在蛋白质复合物形成、蛋白质定位、遗传和翻译调控中发挥作用。在本文中,我们回顾了支持在这些位点翻译 mRNA 的证据、其形成机制的细节及其可能的功能意义。最后,我们将探讨细胞中这些难以捉摸的结构的主要不确定性。本文归类于翻译 翻译 > 机制 RNA 输出和定位 > RNA 定位 翻译 > 调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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