Altering cold-regulated gene expression decouples the salicylic acid-growth trade-off in Arabidopsis.

IF 10 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Plant Cell Pub Date : 2024-10-03 DOI:10.1093/plcell/koae210
María A Ortega, Rhodesia M Celoy, Francisco Chacon, Yinan Yuan, Liang-Jiao Xue, Saurabh P Pandey, MaKenzie R Drowns, Brian H Kvitko, Chung-Jui Tsai
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引用次数: 0

Abstract

In Arabidopsis (Arabidopsis thaliana), overproduction of salicylic acid (SA) increases disease resistance and abiotic stress tolerance but penalizes growth. This growth-defense trade-off has hindered the adoption of SA-based disease management strategies in agriculture. However, investigation of how SA inhibits plant growth has been challenging because many SA-hyperaccumulating Arabidopsis mutants have developmental defects due to the pleiotropic effects of the underlying genes. Here, we heterologously expressed a bacterial SA synthase gene in Arabidopsis and observed that elevated SA levels decreased plant growth and reduced the expression of cold-regulated (COR) genes in a dose-dependent manner. Growth suppression was exacerbated at below-ambient temperatures. Severing the SA-responsiveness of individual COR genes was sufficient to overcome the growth inhibition caused by elevated SA at ambient and below-ambient temperatures while preserving disease- and abiotic-stress-related benefits. Our results show the potential of decoupling SA-mediated growth and defense trade-offs for improving crop productivity.

改变拟南芥中受冷调节基因的表达,使水杨酸-生长权衡脱钩。
在拟南芥(Arabidopsis thaliana)中,过量产生水杨酸(SA)会增强抗病性和非生物胁迫耐受性,但会影响生长。这种生长-防御权衡阻碍了在农业中采用基于水杨酸的病害管理策略。然而,研究 SA 如何抑制植物生长一直是个挑战,因为许多 SA 高积累拟南芥突变体都会因潜在基因的多效应而出现发育缺陷。在这里,我们在拟南芥中异源表达了细菌的 SA 合成酶基因,并观察到 SA 水平的升高以剂量依赖的方式降低了植物的生长并减少了冷调节(COR)基因的表达。在低于环境温度时,生长抑制会加剧。切断单个 COR 基因对 SA 的反应性足以克服 SA 升高在环境温度和低于环境温度下造成的生长抑制,同时保留与疾病和非生物胁迫相关的益处。我们的研究结果表明,将 SA 介导的生长和防御权衡解耦有可能提高作物产量。
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来源期刊
Plant Cell
Plant Cell 生物-生化与分子生物学
CiteScore
16.90
自引率
5.20%
发文量
337
审稿时长
2.4 months
期刊介绍: Title: Plant Cell Publisher: Published monthly by the American Society of Plant Biologists (ASPB) Produced by Sheridan Journal Services, Waterbury, VT History and Impact: Established in 1989 Within three years of publication, ranked first in impact among journals in plant sciences Maintains high standard of excellence Scope: Publishes novel research of special significance in plant biology Focus areas include cellular biology, molecular biology, biochemistry, genetics, development, and evolution Primary criteria: articles provide new insight of broad interest to plant biologists and are suitable for a wide audience Tenets: Publish the most exciting, cutting-edge research in plant cellular and molecular biology Provide rapid turnaround time for reviewing and publishing research papers Ensure highest quality reproduction of data Feature interactive format for commentaries, opinion pieces, and exchange of information in review articles, meeting reports, and insightful overviews.
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