The Effect of Phytocannabinoids and Endocannabinoids on Nrf2 Activity in the Central Nervous System and Periphery.

IF 3.2 Q2 CLINICAL NEUROLOGY
Pietro Marini, Mauro Maccarrone, Luciano Saso, Paolo Tucci
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引用次数: 0

Abstract

The relationship between nuclear factor erythroid 2-related factor 2 (Nrf2) and phytocannabinoids/endocannabinoids (pCBs/eCBs) has been investigated in a variety of models of peripheral illnesses, with little clarification on their interaction within the central nervous system (CNS). In this context, evidence suggests that the Nrf2-pCBs/eCBS interaction is relevant in modulating peroxidation processes and the antioxidant system. Nrf2, one of the regulators of cellular redox homeostasis, appears to have a protective role toward damaging insults to neurons and glia by enhancing those genes involved in the regulation of homeostatic processes. Specifically in microglia and macroglia cells, Nrf2 can be activated, and its signaling pathway modulated, by both pCBs and eCBs. However, the precise effects of pCBs and eCBs on the Nrf2 signaling pathway are not completely elucidated yet, making their potential clinical employment still not fully understood.

植物大麻素和内源性大麻素对中枢神经系统和外周 Nrf2 活性的影响
核因子红细胞生成素 2 相关因子 2(Nrf2)与植物大麻素/内大麻素(pCBs/eCBs)之间的关系已在多种外周疾病模型中进行了研究,但对它们在中枢神经系统(CNS)中的相互作用却知之甚少。在这种情况下,有证据表明,Nrf2-PCBs/eCBS 的相互作用与调节过氧化过程和抗氧化系统有关。Nrf2 是细胞氧化还原平衡的调节因子之一,它通过增强那些参与调节平衡过程的基因,似乎对神经元和神经胶质细胞受到的损伤起到保护作用。特别是在小胶质细胞和大胶质细胞中,Nrf2 可被 pCB 和 eCB 激活并调节其信号通路。然而,pCBs 和 eCBs 对 Nrf2 信号通路的确切影响尚未完全阐明,因此它们在临床上的潜在用途仍不完全清楚。
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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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