Predictive value of Doppler echocardiography parameters for cardiovascular events in patients with systemic lupus erythematosus.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI:10.1177/09612033241266083
Li-Ping Lai, Liang-Qin Wang, Shui-Ping Li
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Abstract

Background and objectives: This study aimed to assess the utility of Doppler echocardiography in evaluating left ventricular diastolic function, and prognosis in patients with systemic lupus erythematosus (SLE).

Patients and methods: A total of 286 SLE patients were selected along with 100 age- and gender-matched healthy individuals who underwent physical examinations. Clinical baseline characteristics were collected. Various Doppler echocardiographic parameters were measured and analyzed, including left ventricular posterior wall thickness (LVPWT), interventricular septal diameter (IVSD), left ventricular mass (LVM), LVM index (LVMI), and others.

Results: Compared to the control group, SLE patients exhibited significantly higher levels of C-reactive protein and lower levels of complement (C) 3 and C4 (p < .001). Doppler echocardiographic parameters showed significant differences between SLE patients and healthy controls, including increased LVPWT, IVSD, LVM, LVMI, peak A, PWI + Tei, E/e', TDI-Tei, and decreased e' and E/A (p < .001). Subgroup analyses indicated more severe ventricular diastolic dysfunction in patients with higher SLE activity and those who experienced cardiovascular events. Correlation analysis revealed positive associations of PWI + Tei, TDI-Tei, and GLS with SLE activity and cardiovascular events (p < .01). Multivariate logistic regression analysis identified LVMI, PWI + Tei, TDI-Tei, and GLS as significant predictors of cardiovascular events (p < .05).

Conclusion: Doppler echocardiography is a valuable tool for the early diagnosis of left ventricular diastolic dysfunction in SLE patients. Key echocardiographic parameters, including LVMI, PWI + Tei, TDI-Tei, and GLS, are effective in predicting cardiovascular events, underscoring the importance of comprehensive cardiac function assessments in these patients.

多普勒超声心动图参数对系统性红斑狼疮患者心血管事件的预测价值。
背景和目的:本研究旨在评估多普勒超声心动图在评估系统性红斑狼疮(SLE)患者左心室舒张功能和预后方面的实用性:共选取了 286 名系统性红斑狼疮患者以及 100 名年龄和性别匹配的健康人进行体检。收集了临床基线特征。测量并分析了各种多普勒超声心动图参数,包括左室后壁厚度(LVPWT)、室间隔直径(IVSD)、左室质量(LVM)、左室质量指数(LVMI)等:与对照组相比,系统性红斑狼疮患者的 C 反应蛋白水平明显升高,补体(C)3 和 C4 水平明显降低(P < .001)。多普勒超声心动图参数显示系统性红斑狼疮患者与健康对照组之间存在明显差异,包括 LVPWT、IVSD、LVM、LVMI、峰值 A、PWI + Tei、E/e'、TDI-Tei 增加,e'和 E/A 减少(P < .001)。亚组分析表明,系统性红斑狼疮活动度较高的患者和发生过心血管事件的患者的心室舒张功能障碍更为严重。相关性分析显示 PWI + Tei、TDI-Tei 和 GLS 与系统性红斑狼疮活动度和心血管事件呈正相关(p < .01)。多变量逻辑回归分析发现,LVMI、PWI + Tei、TDI-Tei 和 GLS 是心血管事件的重要预测因素(P < .05):多普勒超声心动图是早期诊断系统性红斑狼疮患者左心室舒张功能障碍的重要工具。主要的超声心动图参数,包括左心室容积指数(LVMI)、脉搏波速度指数(PWI + Tei)、TDI-Tei 和 GLS,都能有效预测心血管事件的发生,突出了对这些患者进行全面心功能评估的重要性。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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