Different immunological patterns of Down syndrome patients with and without recurrent infections

IF 2.8 4区医学 Q1 PEDIATRICS

Jornal de pediatria Pub Date : 2024-07-22 DOI:10.1016/j.jped.2024.06.007

Kamila Rosa Martins , Flavia Araujo Alves , Luiz Roberto da Silva , Lauren Olivia Alves da Silva , Gesmar Rodrigues Silva Segundo

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引用次数: 0

Abstract

Objective

Individuals with Down Syndrome (DS) exhibit a higher susceptibility to infections, suggesting potential immunological alterations within this population. Consequently, this study aims to assess the immune response profile in children with DS to identify potential immune dysfunctions associated with recurrent infections.

Methods

The authors conducted a retrospective analysis involving 49 DS patients, examining various epidemiological, clinical, cytogenetic, and laboratory variables. The studyʼs sample comprised patients aged 2–20 years, with a predominance of males. These patients were categorized into two groups based on the presence or absence of recurrent infections, as indicated by the Jeffrey Modell Foundation alert signs.

Results

Immunoglobulin (Ig) A, G, and M levels were deemed normal, although individuals with DS experiencing recurrent infections exhibited significantly lower IgA levels. Additionally, CD3, CD4, CD8, and CD19 lymphocyte counts were found to be within normal ranges, with no significant differences between the two groups. While overall data indicated normal seroconversion levels of pneumococcal polysaccharide antibodies, a notable impairment in seroconversion was observed among DS patients with recurrent infections compared to those without such infections.

Conclusion

The deficiency of anti-polysaccharide antibodies in individuals with DS may constitute an important immunological comorbidity. Therefore, it warrants further investigation, particularly among individuals with recurrent infections.

查看原文本刊更多论文

唐氏综合征患者反复感染和未反复感染的不同免疫模式。

目的：唐氏综合征（DS）患者对感染的易感性较高，这表明该人群中存在潜在的免疫学改变。因此，本研究旨在评估唐氏综合征患儿的免疫反应谱，以确定与反复感染有关的潜在免疫功能障碍：作者对 49 名 DS 患者进行了回顾性分析，检查了各种流行病学、临床、细胞遗传学和实验室变量。研究样本包括 2-20 岁的患者，男性居多。根据杰弗里-莫德尔基金会（Jeffrey Modell Foundation）的警戒体征，这些患者根据有无反复感染被分为两组：免疫球蛋白（Ig）A、G和M水平均正常，但反复感染的DS患者的IgA水平明显较低。此外，CD3、CD4、CD8 和 CD19 淋巴细胞计数均在正常范围内，两组之间无明显差异。虽然总体数据显示肺炎球菌多糖抗体的血清转换水平正常，但与无反复感染的患者相比，有反复感染的DS患者的血清转换能力明显下降：结论：DS 患者抗多糖抗体缺乏可能是一种重要的免疫合并症。结论：DS 患者抗多糖抗体缺乏可能是一种重要的免疫合并症，因此值得进一步研究，尤其是在反复感染者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal de pediatria 医学-小儿科

CiteScore

5.60

自引率

3.00%

发文量

审稿时长

43 days

期刊介绍： Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.