Subcutaneous and Visceral Adipose Tissue Reference Values From the Framingham Heart Study Thoracic and Abdominal CT.

IF 7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Investigative Radiology Pub Date : 2024-07-25 DOI:10.1097/RLI.0000000000001104

J Peter Marquardt, P Erik Tonnesen, Nathaniel D Mercaldo, Alexander Graur, Brett Allaire, Mary L Bouxsein, Elizabeth J Samelson, Douglas P Kiel, Florian J Fintelmann

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引用次数: 0

Abstract

Background: Computed tomography (CT) captures the quantity, density, and distribution of subcutaneous and visceral (SAT and VAT) adipose tissue compartments. These metrics may change with age and sex.

Objective: The study aims to provide age-, sex-, and vertebral level-specific reference values for SAT on chest CT and for SAT and VAT on abdomen CT.

Materials and methods: This secondary analysis of an observational study describes SAT and VAT measurements in participants of the Framingham Heart Study without known cancer diagnosis who underwent at least 1 of 2 CT examinations between 2002 and 2011. We used a previously validated machine learning-assisted pipeline and rigorous quality assurance to segment SAT at the fifth, eighth, and tenth thoracic vertebra (T5, T8, T10) and SAT and VAT at the third lumbar vertebra (L3). For each metric, we measured cross-sectional area (cm2) and mean attenuation (Hounsfield units [HU]) and calculated index (area/height2) (cm2/m2) and gauge (attenuation × index) (HU × cm2/m2). We summarized body composition metrics by age and sex and modeled sex-, age-, and vertebral level-specific reference curves.

Results: We included 14,898 single-level measurements from up to 4 vertebral levels of 3797 scans of 3730 Framingham Heart Study participants (1889 [51%] male with a mean [standard deviation] age of 55.6 ± 10.6 years; range, 38-81 years). The mean VAT index increased with age from 65 (cm2/m2) in males and 29 (cm2/m2) in females in the <45-year-old age group to 99 (cm2/m2) in males and 60 (cm2/m2) in females in >75-year-old age group. The increase of SAT with age was less pronounced, resulting in the VAT/SAT ratio increasing with age. A free R package and online interactive visual web interface allow access to reference values.

Conclusions: This study establishes age-, sex-, and vertebral level-specific reference values for CT-assessed SAT at vertebral levels T5, T8, T10, and L3 and VAT at vertebral level L3.

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弗雷明汉心脏研究胸部和腹部 CT 的皮下和内脏脂肪组织参考值。

背景：计算机断层扫描（CT）可捕捉皮下和内脏脂肪组织（SAT 和 VAT）的数量、密度和分布。这些指标可能会随着年龄和性别的变化而变化：研究旨在为胸部 CT 的 SAT 以及腹部 CT 的 SAT 和 VAT 提供特定年龄、性别和脊椎水平的参考值：这项观察性研究的二次分析描述了弗莱明汉心脏研究参与者的 SAT 和 VAT 测量结果，这些参与者在 2002 年至 2011 年间至少接受了 2 次 CT 检查中的 1 次，且未确诊癌症。我们使用先前验证过的机器学习辅助管道和严格的质量保证来分割第五、第八和第十胸椎（T5、T8 和 T10）的 SAT 以及第三腰椎（L3）的 SAT 和 VAT。对于每项指标，我们都测量了横截面积（cm2）和平均衰减（Hounsfield 单位 [HU]），并计算了指数（面积/身高2）（cm2/m2）和测量值（衰减×指数）（HU ×cm2/m2）。我们按年龄和性别总结了身体成分指标，并建立了性别、年龄和椎体水平特异性参考曲线模型：我们纳入了对 3730 名弗雷明汉心脏研究参与者（1889 名[51%]男性，平均[标准差]年龄为 55.6 ± 10.6 岁；范围为 38-81 岁）的 3797 次扫描中最多 4 个椎体水平的 14898 次单层次测量结果。随着年龄的增长，75 岁年龄组男性的平均 VAT 指数从 65（cm2/m2）增加到 29（cm2/m2）。而 SAT 随年龄的增长则不太明显，导致 VAT/SAT 比值随年龄增长而增加。通过免费的 R 软件包和在线交互式可视化网络界面，可以获得参考值：本研究为椎体 T5、T8、T10 和 L3 水平的 CT 评估 SAT 和椎体 L3 水平的 VAT 确定了年龄、性别和椎体水平特异性参考值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative Radiology 医学-核医学

CiteScore

15.10

自引率

16.40%

发文量

188

审稿时长

4-8 weeks

期刊介绍： Investigative Radiology publishes original, peer-reviewed reports on clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, and related modalities. Emphasis is on early and timely publication. Primarily research-oriented, the journal also includes a wide variety of features of interest to clinical radiologists.