Para rubber seed oil and its fatty acids alleviate photoaging and maintain cell homeostasis

IF 2.7 4区医学 Q2 DERMATOLOGY

International Journal of Cosmetic Science Pub Date : 2024-07-25 DOI:10.1111/ics.13006

Nattaya Lourith, Mayuree Kanlayavattanakul, Mattaka Khongkow, Puxvadee Chaikul

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引用次数: 0

Abstract

Objective

Para rubber seed oil was indicated for skin dullness and hair loss in regard to its cutaneous beneficial fatty acids. Nonetheless, the oil's potency against photoaging remains unexplored. We proposed that para rubber seed oil could alleviate photoaging.

Methods

Para rubber seed oil was investigated in cocultures of human HaCaT cells and dermal fibroblasts (HDF). Photoaging protectant efficiency was monitored in terms of IL-6 and IL-8 as well as MMP-1 (collagenase) and MMP-9 (gelatinase) in a comparison with its fatty acid components.

Results

Para rubber seed oil standardized in fatty acids was indicated as the promising plant oil for photoaging treatment. Its photoprotection mechanism was demonstrated in the coculture system of keratinocyte and fibroblast cells for the first time. Where the oil and its fatty acid constituents (100 μg/mL) were indicated to be safe and efficiently protect the cocultures against UV damage. The oil significantly (p < 0.001) suppressed UV-induced IL-6, IL-8, MMP-1 and MMP-9 secretions. The revealed photoprotection proficiency was abided by its fatty acids, particularly the unsaturated C18 ones.

Conclusion

The oil was indicated on its potential to maintain skin homeostasis and would alleviate senescence ageing in regard to its photoprotection abilities exhibited. Para rubber seed oil is warranted as a new generation of photoaging protectant agent with the profiled safety and efficacy demonstrated in the epidermal coculture system. The findings encourage the development of innovative anti-ageing products containing the oil, which is categorizable as a sustainable specialty material for photoaging treatment.

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顺式橡胶籽油及其脂肪酸可缓解光老化，维持细胞平衡。

目的：顺丁橡胶籽油因含有对皮肤有益的脂肪酸而被用于治疗皮肤晦暗和脱发。然而，这种油对光老化的功效仍有待探索。我们提出对位橡胶籽油可以缓解光老化：方法：在人类 HaCaT 细胞和真皮成纤维细胞（HDF）的共培养物中研究对位橡胶籽油。方法：在人类 HaCaT 细胞和真皮成纤维细胞（HDF）的共培养物中研究对位橡胶籽油对光老化的保护作用，从 IL-6、IL-8 以及 MMP-1（胶原酶）和 MMP-9（明胶酶）的角度对其脂肪酸成分进行比较：结果：脂肪酸标准化的顺式橡胶籽油被认为是有希望用于光老化治疗的植物油。其光保护机制首次在角质细胞和成纤维细胞的共培养系统中得到证实。结果表明，植物油及其脂肪酸成分（100 μg/mL）是安全的，能有效保护共培养物免受紫外线的伤害。该油对紫外线损伤的保护作用明显（p 结论）：该油具有维持皮肤平衡的潜力，并能缓解衰老，具有光保护能力。对位橡胶籽油在表皮细胞培养系统中表现出的安全性和有效性证明，它可以作为新一代光老化保护剂。研究结果鼓励开发含有对位橡胶籽油的创新型抗衰老产品，对位橡胶籽油可归类为一种可持续的光老化治疗特殊材料。

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来源期刊

International Journal of Cosmetic Science DERMATOLOGY-

CiteScore

4.60

自引率

4.30%

发文量

期刊介绍： The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.