Metabolic dysfunction associated fatty liver disease in healthy weight individuals.

IF 5.9 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Hepatology International Pub Date : 2024-10-01 Epub Date: 2024-07-25 DOI:10.1007/s12072-024-10662-w

Nahum Méndez-Sánchez, Willem Pieter Brouwer, Frank Lammert, Yusuf Yilmaz

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Abstract

Metabolic dysfunction associated fatty liver disease (MAFLD) is an increasing public health problem, affecting one third of the global population. Contrary to conventional wisdom, MAFLD is not exclusive to obese or overweight individuals. Epidemiological studies have revealed a remarkable prevalence among healthy weight individuals, leading investigations into the genetic, lifestyle, and dietary factors that contribute to the development of MAFLD in this population. This shift in perspective requires reconsideration of preventive strategies, diagnostic criteria and therapeutic approaches tailored to address the unique characteristics of MAFLD healthy weight individuals. It also underscores the importance of widespread awareness and education, within the medical community and among the general population, to promote a more inclusive understanding of liver metabolic disorders. With this review, we aim to provide a comprehensive exploration of MAFLD in healthy weight individuals, encompassing epidemiological, pathophysiological, and clinical aspects.

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健康体重人群中与脂肪肝相关的代谢功能障碍。

代谢功能障碍相关性脂肪肝（MAFLD）是一个日益严重的公共健康问题，影响着全球三分之一的人口。与传统观念相反，代谢功能障碍相关性脂肪肝并非肥胖或超重人群的专利。流行病学研究显示，健康体重人群的发病率也很高，这促使人们开始研究导致这类人群患 MAFLD 的遗传、生活方式和饮食因素。这种观点的转变要求我们重新考虑预防策略、诊断标准和治疗方法，以解决健康体重人群 MAFLD 的独特性。这也强调了在医学界和普通人群中开展广泛宣传和教育的重要性，以促进人们对肝脏代谢紊乱有更全面的了解。通过这篇综述，我们旨在从流行病学、病理生理学和临床等方面对健康体重人群的 MAFLD 进行全面探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatology International 医学-胃肠肝病学

CiteScore

10.90

自引率

3.00%

发文量

167

审稿时长

6-12 weeks

期刊介绍： Hepatology International is the official journal of the Asian Pacific Association for the Study of the Liver (APASL). This is a peer-reviewed journal featuring articles written by clinicians, clinical researchers and basic scientists is dedicated to research and patient care issues in hepatology. This journal will focus mainly on new and emerging technologies, cutting-edge science and advances in liver and biliary disorders. Types of articles published: -Original Research Articles related to clinical care and basic research -Review Articles -Consensus guidelines for diagnosis and treatment -Clinical cases, images -Selected Author Summaries -Video Submissions