Inflammation unites diverse acute and chronic diseases

IF 4.4 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Peter Libby, Robin Smith, Eric J. Rubin, Marilyn K. Glassberg, Michael E. Farkouh, Robert S. Rosenson
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Abstract

Background

Inflammation and immunity contribute pivotally to diverse acute and chronic diseases. Inflammatory pathways have become increasingly targets for therapy. Yet, despite substantial similarity in mechanisms and pathways, the scientific, medical, pharma and biotechnology sectors have generally focused programs finely on a single disease entity or organ system. This insularity may impede progress in innovation and the harnessing of powerful new insights into inflammation biology ripe for clinical translation.

Methods

A multidisciplinary thinktank reviewed highlights how inflammation contributes to diverse diseases, disturbed homeostasis, ageing and impaired healthspan. We explored how common inflammatory and immune mechanisms that operate in key conditions in their respective domains. This consensus review highlights the high degree of commonality of inflammatory mechanisms in a diverse array of conditions that together contribute a major part of the global burden of morbidity and mortality and present an enormous challenge to public health and drain on resources.

Results

We demonstrate how that shared inflammatory mechanisms unite many seemingly disparate diseases, both acute and chronic. The examples of infection, cardiovascular conditions, pulmonary diseases, rheumatological disorders, dementia, cancer and ageing illustrate the overlapping pathogenesis. We outline opportunities to synergize, reduce duplication and consolidate efforts of the clinical, research and pharmaceutical communities. Enhanced recognition of these commonalties should promote cross-fertilization and hasten progress in this rapidly moving domain.

Conclusions

Greater appreciation of the shared mechanisms should simplify understanding seemingly disparate diseases for clinicians and help them to recognize inflammation as a therapeutic target which the development of novel therapies is rendering actionable.

Abstract Image

炎症将各种急性和慢性疾病联系在一起。
背景:炎症和免疫是导致各种急性和慢性疾病的关键因素。炎症通路日益成为治疗目标。然而,尽管机制和途径非常相似,但科学、医学、制药和生物技术部门一般都将项目重点放在单一疾病实体或器官系统上。这种封闭性可能会阻碍创新的进展,也不利于利用对炎症生物学的强大新见解进行临床转化:一个多学科智囊团回顾了炎症是如何导致各种疾病、体内平衡紊乱、老化和健康受损的。我们探讨了炎症和免疫机制在各自领域的关键条件下是如何共同发挥作用的。这篇共识性综述强调了炎症机制在各种疾病中的高度共性,这些疾病共同造成了全球发病率和死亡率的主要负担,并对公共卫生和资源消耗构成了巨大挑战:结果:我们展示了共同的炎症机制是如何将许多看似不同的疾病(包括急性和慢性疾病)联系在一起的。感染、心血管疾病、肺部疾病、风湿病、痴呆症、癌症和老龄化等例子说明了重叠的发病机制。我们概述了临床、研究和医药界协同合作、减少重复和整合努力的机会。加强对这些共性的认识应能促进交叉融合,加快这一快速发展领域的进展:结论:对共同机制的进一步认识应能简化临床医生对看似不同的疾病的理解,并帮助他们认识到炎症是一个治疗靶点,新型疗法的开发正使其具有可操作性。
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来源期刊
CiteScore
9.50
自引率
3.60%
发文量
192
审稿时长
1 months
期刊介绍: EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.
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