Koala retrovirus and neoplasia: correlation and underlying mechanisms

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2024-08-01 DOI:10.1016/j.coviro.2024.101427

Rachael Tarlinton , Alex D Greenwood

引用次数: 0

Abstract

The koala retrovirus, KoRV, is one of the few models for understanding the health consequences of retroviral colonization of the germline. Such colonization events transition exogenous infectious retroviruses to Mendelian traits or endogenous retroviruses (ERVs). KoRV is currently in a transitional state from exogenous retrovirus to ERV, which in koalas (Phascolarctos cinereus) has been associated with strongly elevated levels of neoplasia. In this review, we describe what is currently known about the associations and underlying mechanisms of KoRV-induced neoplasia.

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考拉逆转录病毒和肿瘤：相关性和潜在机制。

考拉逆转录病毒（KoRV）是了解逆转录病毒在生殖系定植对健康影响的少数模型之一。这种定殖事件将外源性传染性逆转录病毒转变为孟德尔性状或内源性逆转录病毒（ERVs）。KoRV 目前正处于从外源性逆转录病毒到 ERV 的过渡阶段，考拉（Phascolarctos cinereus）的肿瘤发病率与此密切相关。在这篇综述中，我们将介绍目前已知的有关 KoRV 诱发肿瘤的关联和内在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.