The Difficulty in Defining the True High-Risk Smoldering Myeloma.

IF 10 1区医学 Q1 ONCOLOGY

Clinical Cancer Research Pub Date : 2024-10-01 DOI:10.1158/1078-0432.CCR-24-1382

Niels Weinhold, Leo Rasche

引用次数: 0

Abstract

Early intervention trials have been initiated for the precursor disease smoldering myeloma (SMM). A recent study showed that genomic complexity varies widely among patients treated for high-risk SMM and is associated with response to triplet therapy, suggesting that established clinical risk scores often fail to discriminate between stable and aggressive disease. See related article by Kazandjian et al., p. 4482.

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难以确定真正的高危烟雾型骨髓瘤

针对前驱疾病烟雾型骨髓瘤（SMM）的早期干预试验已经启动。最近的一项研究表明，在接受治疗的高危SMM患者中，基因组复杂性差异很大，而且与三联疗法的反应有关，这表明既有的临床风险评分往往无法区分稳定型和侵袭性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Cancer Research 医学-肿瘤学

CiteScore

20.10

自引率

1.70%

发文量

1207

审稿时长

2.1 months

期刊介绍： Clinical Cancer Research is a journal focusing on groundbreaking research in cancer, specifically in the areas where the laboratory and the clinic intersect. Our primary interest lies in clinical trials that investigate novel treatments, accompanied by research on pharmacology, molecular alterations, and biomarkers that can predict response or resistance to these treatments. Furthermore, we prioritize laboratory and animal studies that explore new drugs and targeted agents with the potential to advance to clinical trials. We also encourage research on targetable mechanisms of cancer development, progression, and metastasis.