Menopausal age does not affect ventricular structure and function: a Mendelian randomization study.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2024-10-01 Epub Date: 2024-07-25 DOI:10.1080/13697137.2024.2380009

Youjie Zeng, Si Cao, Yuan Yuan

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引用次数: 0

Abstract

Objectives: Observational studies have suggested an association between age at natural menopause (ANM) and ventricular structure and function. Nevertheless, the causal relationship remains unclear. This study aimed to evaluate the causal effects of ANM on ventricular structure and function by Mendelian randomization (MR) analysis.

Methods: Genome-wide association summary statistics for ANM and 16 ventricular structures and functions were obtained. The inverse variance weighted (IVW) method was the primary MR approach for assessing causal associations. In addition, three additional MR methods (MR-Egger, weighted median and weighted mode) were performed to complement the IVW method. Furthermore, various sensitivity tests were conducted to evaluate the reliability of the MR results.

Results: The IVW method identified no causal association between ANM and all 16 ventricular structures or functions (p > 0.05). Three additional MR methods yielded parallel results to the IVW approach (p > 0.05). Various sensitivity tests revealed stability of the MR results, indicating no heterogeneity or horizontal pleiotropy.

Conclusion: The present MR study indicated that ANM would not causally affect ventricular structure or function. Therefore, the correlation between ANM and ventricular characteristics in previous observational studies might be attributed to shared upstream cardiovascular risk factors or unidentified genetic mutations that simultaneously affect both ANM and ventricular structure and function.

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绝经年龄不会影响心室结构和功能：孟德尔随机研究。

目的：观察性研究表明，自然绝经年龄（ANM）与心室结构和功能之间存在关联。然而，其中的因果关系仍不清楚。本研究旨在通过孟德尔随机化（MR）分析评估自然绝经年龄对心室结构和功能的因果影响：方法：获得 ANM 与 16 种心室结构和功能的全基因组关联汇总统计。反方差加权（IVW）法是评估因果关联的主要 MR 方法。此外，还采用了另外三种 MR 方法（MR-Egger、加权中位数和加权模式）来补充 IVW 方法。此外，还进行了各种敏感性测试，以评估 MR 结果的可靠性：结果：IVW方法未发现ANM与所有16个心室结构或功能之间存在因果关系（P>0.05）。另外三种磁共振方法得出的结果与 IVW 方法相同（P > 0.05）。各种敏感性测试显示 MR 结果稳定，表明没有异质性或水平多向性：本磁共振研究表明，ANM 不会对心室结构或功能产生因果影响。因此，以往观察性研究中 ANM 与心室特征之间的相关性可能归因于共同的上游心血管风险因素或同时影响 ANM 和心室结构与功能的未识别基因突变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.