Life-Threatening Anaphylaxis due to Cerebrolysin®.

IF 0.9 Q4 CLINICAL NEUROLOGY
Case Reports in Neurological Medicine Pub Date : 2024-07-18 eCollection Date: 2024-01-01 DOI:10.1155/2024/2332908
Helmut Trimmel, Wolfgang Tauber, Martin Zikeli
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引用次数: 0

Abstract

In this case report, we describe a well-documented, severe anaphylactic reaction after intravenous administration of cerebrolysin, a neurotrophic agent derived from highly purified porcine brain tissue, consisting of peptides and free amino acids. Cerebrolysin has been in use for decades, in various neurological diseases, but especially stroke and traumatic brain injury, with the aim of enhancing cognitive performance. After administration of cerebrolysin to an 85-year-old male patient suffering from subacute stroke, he developed a fulminant anaphylactic reaction. Following institutional standards, vital functions were quickly restored. The anaphylactic reaction was clearly confirmed by laboratory tests. To date, only rare cases of anaphylaxis due to cerebrolysin have been published in the literature. The current report is intended to raise awareness for the possibility of such a reaction, given the widespread use of cerebrolysin in several indications in mostly critical patients. The case shows how a completely unexpected life-threatening situation can be successfully treated by targeted measures, if the situation is recognized quickly. In light of this event, we consider pathophysiology of allergic reactions and treatment guidelines.

脑活素®引起的危及生命的过敏性休克。
在本病例报告中,我们描述了静脉注射脑溶解素后出现严重过敏反应的有据可查的病例。脑溶解素是从高度纯化的猪脑组织中提取的一种神经营养剂,由多肽和游离氨基酸组成。几十年来,脑溶解素一直被用于治疗各种神经系统疾病,尤其是中风和脑外伤,目的是提高认知能力。一名 85 岁的男性亚急性中风患者在服用脑蛋白酶后,出现了剧烈的过敏反应。按照机构标准,生命功能很快得到恢复。过敏反应经实验室检测得到明确证实。迄今为止,文献中只发表过极少数因脑溶酶类引起的过敏性休克病例。鉴于脑蛋白酵素在多种适应症中广泛用于危重病人,本报告旨在提高人们对这种反应可能性的认识。该病例表明,如果能迅速识别情况,就可以通过有针对性的措施成功治疗完全出乎意料的危及生命的情况。鉴于这一事件,我们考虑了过敏反应的病理生理学和治疗指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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自引率
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发文量
26
审稿时长
11 weeks
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