Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer.

Q3 Medicine
Mahdieh Parvizi, Mehrshad Abbasi, Hojjat Ahmadzadehfar, Abbas Tafakhori, Maryam Naseri, Ali Khalaj, Saeed Farzanehfar
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引用次数: 0

Abstract

Objectives: The bio-distribution of Tc-99m HMPAO labeled platelets (LP), which could be used to image subtle thrombosis, is not reported in a human yet, which is the subject of the current study.

Method: The platelets were extracted from 49 ml whole blood and labeled with Tc-99m HMPAO, then re-injected to the healthy volunteer. Anterior and posterior whole body imaging was done by a dual-head gamma camera 3, 18, 33, 46, 81, 124, 190 min and 15 hours after injection. Also a whole-body SPECT was done at 137 min post-injection. The area under the curves of the spleen, liver, left kidney, bladder, right lung, brain, and abdominal aorta ROIs was calculated to estimate the accumulation of labeled platelets within the organs.

Results: The spleen was the target organ. The kidneys, liver, and heart were also remarkably visualized. The thyroid, stomach, bladder, or gastrointestinal (GI) uptake/activity was not significant. The stomach visualization was enhanced after ingestion at 60 min. The sagittal and lateral sinuses were delineated, and the background of the brain was very low. During the study, the area under the curve of activity was 738, 308, 302, 196, 230, 121, 79, 216, 529, 369, 162, and 54 counts. min/pixel for spleen, liver, heart, right lung, left kidney, right iliac artery, sagittal sinus, thyroid, bladder, stomach, GI, and background, respectively.

Conclusion: The quality of the scan with low dose Tc-99m HMPAO LPs is optimal. We documented the bio-distribution of LPs. The optimal imaging time was 80-120 min post-injection when the free Tc-99m and GI transit were negligible. The sagittal and lateral sinuses were visualized enabling detection of possible clots in the vessels.

健康志愿者体内 Tc-99m HMPAO 标记血小板的生物分布研究。
研究目的:锝-99m HMPAO标记血小板(LP)可用于对细微血栓形成进行成像,但目前还没有关于其在人体中的生物分布的报道,这正是本研究的主题:方法:从 49 毫升全血中提取血小板并用 Tc-99m HMPAO 标记,然后重新注射到健康志愿者体内。注射后3、18、33、46、81、124、190分钟和15小时,使用双头伽马相机进行前后全身成像。此外,还在注射后 137 分钟进行了全身 SPECT 扫描。计算脾脏、肝脏、左肾、膀胱、右肺、大脑和腹主动脉ROI的曲线下面积,以估计标记血小板在器官内的积聚情况:结果:脾脏是目标器官。结果:脾脏是目标器官,肾脏、肝脏和心脏也明显可见。甲状腺、胃、膀胱或胃肠道(GI)的摄取/活性不明显。摄入 60 分钟后,胃的可视化增强。矢状窦和外侧窦清晰可见,脑部背景非常低。研究期间,脾脏、肝脏、心脏、右肺、左肾、右髂动脉、矢状窦、甲状腺、膀胱、胃、消化道和背景的活动曲线下面积分别为 738、308、302、196、230、121、79、216、529、369、162 和 54 计数:结论:低剂量 Tc-99m HMPAO LPs 的扫描质量最佳。我们记录了 LPs 的生物分布。最佳成像时间为注射后 80-120 分钟,此时游离锝-99m 和胃肠道转运可忽略不计。矢状窦和外侧窦的可视化使我们能够发现血管中可能存在的血栓。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Asia Oceania Journal of Nuclear Medicine and Biology
Asia Oceania Journal of Nuclear Medicine and Biology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
1.80
自引率
0.00%
发文量
28
审稿时长
12 weeks
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