Novel neutrophil biology insights underlying atypical chemokine receptor-1/Duffy antigen receptor of chemokines-associated neutropenia.

IF 3.1 3区 医学 Q2 HEMATOLOGY
Current Opinion in Hematology Pub Date : 2024-11-01 Epub Date: 2024-07-24 DOI:10.1097/MOH.0000000000000834
Johnson M Liu, Hongbo R Luo
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引用次数: 0

Abstract

Purpose of review: Atypical chemokine receptor-1 (ACKR1)/Duffy antigen receptor of chemokines (DARC)-associated neutropenia (ADAN; OMIM 611862), previously named benign ethnic neutropenia, and present in two-thirds of individuals identifying as Black in the USA, is associated with mild to moderate decreases in peripheral neutrophil counts that nevertheless do not lead to increased infections. Consequently, recent initiatives have sought to establish normal neutrophil count reference ranges for ADAN, considering it a normal variant rather than a clinical disorder requiring medical intervention.

Recent findings: A limited number of studies elucidating the mechanism of neutropenia in ADAN has suggested that neutrophils may redistribute from peripheral blood to the tissues including the spleen: this might explain why ADAN is not associated with increased risks of infection since the total number of neutrophils in the body remains normal. In this review, we critically examine the research underlying the molecular basis of ADAN.

Summary: Insights into the biology of neutrophils and their trafficking may inform the clinical interpretation of neutropenia in ADAN. The bulk of research suggests that ADAN does not lead to a diminished host defense as do other forms of neutropenia. However, ADAN may lead to increased proinflammatory signaling, with possible implications for senescence of the immune system and predisposition to autoimmunity and cancer.

非典型趋化因子受体-1/达菲抗原受体与中性粒细胞减少症相关的中性粒细胞生物学新见解。
综述目的:非典型趋化因子受体-1(ACKR1)/达菲趋化因子抗原受体(DARC)相关性中性粒细胞减少症(ADAN;OMIM 611862),以前被命名为良性种族中性粒细胞减少症,在美国有三分之二的黑人患有该病,其外周中性粒细胞计数轻度至中度下降,但不会导致感染增加。因此,最近的一些倡议试图为 ADAN 建立正常的中性粒细胞计数参考范围,认为这是一种正常的变异,而不是一种需要医疗干预的临床疾病:少数阐明 ADAN 中性粒细胞减少机制的研究表明,中性粒细胞可能会从外周血重新分布到包括脾脏在内的组织中:这或许可以解释为什么 ADAN 与感染风险增加无关,因为体内中性粒细胞的总数仍然正常。在这篇综述中,我们将严格审查有关 ADAN 分子基础的研究。摘要:对中性粒细胞及其迁移生物学的深入了解可能会为 ADAN 中性粒细胞减少症的临床解释提供依据。大部分研究表明,ADAN 不会像其他形式的中性粒细胞减少症那样导致宿主防御能力下降。不过,ADAN 可能会导致促炎信号的增加,从而可能影响免疫系统的衰老以及自身免疫和癌症的易感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.60
自引率
3.10%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.
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