Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Current Neurology and Neuroscience Reports Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI:10.1007/s11910-024-01365-8

Noemi Piramide, Rosa De Micco, Mattia Siciliano, Marcello Silvestro, Alessandro Tessitore

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Abstract

Purpose of the review: In this review, we attempt to summarize the most updated studies that applied resting-state functional magnetic resonance imaging (rs-fMRI) in the field of Parkinsonisms and related dementia.

Recent findings: Over the past decades, increasing interest has emerged on investigating the presence and pathophysiology of cognitive symptoms in Parkinsonisms and their possible role as predictive biomarkers of neurodegenerative brain processes. In recent years, evidence has been provided, applying mainly three methodological approaches (i.e. seed-based, network-based and graph-analysis) on rs-fMRI data, with promising results. Neural correlates of cognitive impairment and dementia have been detected in patients with Parkinsonisms along the diseases course. Interestingly, early functional connectivity signatures were proposed to track and predict future progression of neurodegenerative processes. However, longitudinal studies are still sparce and further investigations are needed to overcome this knowledge gap.

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帕金森氏症及相关痴呆症的静息状态功能磁共振成像方法。

综述的目的：在这篇综述中，我们试图总结在帕金森病和相关痴呆症领域应用静息态功能磁共振成像（rs-fMRI）的最新研究：过去几十年来，人们对帕金森病认知症状的存在和病理生理学及其作为脑神经退行性过程的预测性生物标志物的可能作用的研究兴趣与日俱增。近年来，主要有三种方法（即基于种子的方法、基于网络的方法和图分析方法）应用于 rs-fMRI 数据，并取得了令人鼓舞的成果。在帕金森病患者的病程中发现了认知障碍和痴呆的神经相关性。有趣的是，有人提出早期功能连接特征可用于跟踪和预测神经退行性过程的未来进展。然而，纵向研究仍然很少，需要进一步的研究来填补这一知识空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.