Teite Rebecca Hildebrandt, Helmut Ramharter, Anita Lumeka Kabwende, Lilian Endamne, Saskia D Davi, Ayôla Akim Adegnika, Ghyslain Mombo-Ngoma, Selidji T Agnandji, Johannes Mischlinger, Rella Manego Zoleko, Michael Ramharter
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引用次数: 0
Abstract
Loiasis, a filarial pathogen exclusively endemic in central and western Africa, causes a wide spectrum of symptoms. Understanding the breadth of its clinical manifestations is of importance for adequate patient care and to understand its disease burden. Recurring transient pain in the oral cavity was reported as a self-perceived symptom of loiasis in in-depth interviews of patients in a high transmission region in Gabon. Pain was described as stabbing in character and transient for a few days in its temporal course. A quantitative epidemiological survey indicated that transient tooth pain was experienced by 22% of patients infected with Loa loa. Among those individuals, it was exclusively reported by patients suffering from migratory loiasis (24%). Similar findings have been previously described for other filarial pathogens, indicating that transient swellings of the periodontium and the soft tissue of the oral cavity may explain this symptom reported by patients with migratory loiasis.
丝虫病是一种仅在非洲中部和西部流行的丝虫病原体，可引起多种症状。了解其临床表现的广泛性对于充分护理病人和了解其疾病负担非常重要。在对加蓬一个高传播地区的患者进行的深入访谈中发现，口腔中反复出现的短暂疼痛是一种自我感觉良好的丝虫病症状。据描述，这种疼痛具有刺痛的特点，在时间过程中会持续数天。一项定量流行病学调查显示，22% 的 Loa loa 感染者经历过短暂的牙痛。在这些人中，仅有 24% 的迁徙性 Loiasis 患者报告过这种情况。以前对其他丝虫病原体也有过类似的发现，表明牙周和口腔软组织的一过性肿胀可能是游走性丝虫病患者报告的这一症状的原因。
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The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine.
The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development.
The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal.
Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries
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