Platelet rich fibrin augmented tympanoplasty versus cartilage tympanoplasty: a randomized clinical trial.

IF 1.9 3区医学 Q2 OTORHINOLARYNGOLOGY

European Archives of Oto-Rhino-Laryngology Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI:10.1007/s00405-024-08819-2

Ahmad Muhammad Al-Arman, Waleed Moneir, Hazem Emam Amer, Hisham Atef Ebada

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Abstract

Objectives: The aim of the current study was to evaluate the efficacy of PRF-augmented fascia tympanoplasty versus cartilage tympanoplasty in repair of large TM perforations.

Methods: This randomized clinical trial included 156 patients with dry large tympanic membrane perforations. Patients were randomly allocated into 2 groups, cartilage tympanoplasty group (n = 77) and platelet rich fibrin (PRF) augmented tympanoplasty group (n = 79). Graft take rates, hearing outcomes, operative time, and postoperative complications were documented and compared.

Results: Graft take rate was 96.1% in the cartilage group and 93.7% PRF group with no statistically significant difference. Operative time was significantly longer in the cartilage group. No differences in the hearing outcomes and postoperative complications were reported.

Conclusion: Application of PRF on the fascia in tympanoplasty promotes healing of the tympanic membrane. PRF is safe, cheap, readily available, and easily prepared and applied. It increases the success rates of large tympanic membrane perforations without the need for cartilage grafts.

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富血小板纤维蛋白鼓室成形术与软骨鼓室成形术：随机临床试验。

研究目的本研究旨在评估PRF增强筋膜鼓室成形术与软骨鼓室成形术在修复大型鼓膜穿孔方面的疗效：这项随机临床试验包括156名鼓膜干性大穿孔患者。患者被随机分为两组，软骨鼓室成形术组（n = 77）和富血小板纤维蛋白（PRF）增强鼓室成形术组（n = 79）。记录并比较了移植物取出率、听力效果、手术时间和术后并发症：结果：软骨组的移植取材率为 96.1%，PRF 组为 93.7%，两者在统计学上无显著差异。软骨组的手术时间明显更长。听力结果和术后并发症无差异：结论：鼓室成形术中在筋膜上应用 PRF 可促进鼓膜愈合。PRF安全、廉价、易于获得、易于制备和应用。它能提高大面积鼓膜穿孔的成功率，而无需软骨移植。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.