Paper-based sensing of pancreatic-cancer biomarker α-chymotrypsin through turn-on lanthanide-luminescence†

IF 3.5 Q2 CHEMISTRY, ANALYTICAL
Ananya Biswas and Uday Maitra
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引用次数: 0

Abstract

We report the facile detection of a pancreatic cancer biomarker α-chymotrypsin (Chy) by turn-on, time-gated lanthanide luminescence for the first time. To the best of our knowledge, the non-peptide probe we designed is the simplest one currently available. The probe undergoes Chy-induced release of the sensitizing antenna (2,3-dihydroxynaphthalene), leading to enhanced lanthanide luminescence. The detection protocol was further modified to develop a paper-based sensor and was used to detect Chy in commercial tablets, and to rapidly screen Chy-inhibitors.

Abstract Image

基于纸张的胰腺癌生物标记物 α-Chymotrypsin 触发镧系元素发光传感技术
我们首次报道了利用开启的时间门控镧系元素发光法检测胰腺癌生物标志物α-糜蛋白酶(Chy)的简便方法。据我们所知,我们设计的非肽探针是目前最简单的探针。该探针会在 Chy 诱导下释放敏化天线(2,3-二羟基萘),从而导致镧系元素发光增强。该检测方案经进一步修改后被用于开发纸基传感器,并被用于检测商业药片中的糜蛋白酶和快速筛选糜蛋白酶抑制剂。
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来源期刊
CiteScore
2.30
自引率
0.00%
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